Supplement Tips & Questions

Pro Hormones – What You Need To Know In 2024 (Updated)

Prohormones have been a staple in the fitness and bodybuilding community since 1996. Over the years, these compounds have undergone significant transformations, especially in light of the regulatory landscape introduced in 2004. The laws implemented then were designed to ensure prohormones’ safety, efficacy, and legality. This marked a turning point, leading to a new generation of prohormones that aim to deliver results with fewer associated risks and side effects.

While the current generation of prohormones is not entirely free from potential drawbacks, the risks have been substantially reduced. It remains crucial for users to be well-informed about the specific prohormones they choose, ensuring they align with their fitness goals and are cycled correctly. Our comprehensive guide covers essential aspects of prohormone use to aid in this journey, from common compounds to stacking strategies, potential side effects, and the critical role of post-cycle therapy (PCT).

In this guide, we’re going to go over: 

  1. Common Prohormone Compounds:
    1. Explore a diverse range of prohormone compounds available in the market today.
    2. Understand the unique characteristics and benefits of each compound.
    3. Learn about the suitability of different prohormones for specific fitness goals.
  2. Stacks/Cycles:
    1. Delve into effective prohormone stacking strategies to optimize results.
    2. Understand how combining different compounds can enhance performance and muscle gains.
    3. Receive guidance on planning cycles to maximize benefits while minimizing potential risks.
  3. Side Effects:
    1. Gain insights into potential side effects associated with prohormone use.
    2. Understand the importance of monitoring and addressing side effects promptly.
    3. Learn how to mitigate risks through responsible use and proper supplementation.
  4. Importance of PCT’s (Post-Cycle Therapy):
    1. Explore the crucial role of post-cycle therapy in maintaining gains and hormonal balance.

If you don’t see a pro hormone you want us to go over, leave a comment below or send us an email.

 

pro hormones old vs new

What Are Pro Hormones?

Pro hormones are compounds that are precursors to hormones and can be converted into active hormones in the body. Bodybuilders and athletes often use them to increase muscle mass, strength, and performance. When you take a pro hormone, it converts to anabolic hormones in the body. The resulting effects are seen through several pathways. But, generally, the most important effects are on the body’s Androgenic, Estrogenic, and Progestogenic receptors. Like anabolic steroids, pro hormones are androgen receptor agonists. A strong androgen receptor agonist will present effects related to increased testosterone.†

Some effects can include increased:

  • Aggression†
  • Sex drive†
  • Muscle strength†
  • Muscle mass†
  • Muscles feel denser and more solid †

As well as an increased risk of side effects related to high androgen levels.

These can include but are not limited to increased susceptibility to hair loss and acne.†

Pro hormones also affect your estrogenic and progestogenic receptors, which react similarly. Pro hormones that convert to estrogen and progesterone can support increased mass and strength.†

However, the catch is that considerable mass gains are often lost after the cycle is over. This is likely due to water retention more than anything else. This conversion also comes with its own set of risks and sides. Estrogenic side effects can include, but are not limited to:

  • Increased water weight†
  • Increased susceptibility to fat gain†
  • And gynecomastia (swelling of the breast tissue in men)†

Pro hormones are often categorized as being androgenic, estrogenic, or even both. This is typically based on their primary method of action. All pro hormones will have an androgenic effect to some degree. But, each pro hormone can differ in its impact on other body systems.†

Typically, strong androgens are useful for promoting strength gains. This is via the central nervous system (CNS) stimulation. Therefore, a strong androgen is often similar to Dihydrotestosterone (DHT). Furthermore, some will promote enhanced red blood cell production, which is why users usually experience larger pumps and vascularity.†

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What’s Changed?

As we mentioned before, the pro hormones available today differ from those available before the US Congress passed the Anabolic Steroid Control Act of 2004. The new generation of pro hormones has a better delivery system and absorption rate. This means it’s not as taxing on your liver.†

Liposomal Delivery System:

Liposomal technology has been used in the medical field as a carrier for drugs. But only now has it made its way into nutrition supplements. Liposomes have a hydrophobic core with a hydrophilic shell. This simultaneously protects the molecule from degradation while allowing it to be more soluble.†

Cyclosome™ Delivery:

Cyclosome™ Technology is another liposomal delivery technology. This approach can help increase pro hormone solubility and vesicle stability. This delivery method controls the in vivo fate of hydrophobic compounds and avoids the burst release of pro hormones from the vesicle. This allows the ‘Trojan Horse’ to deliver pro hormones and testosterone boosters to the systemic circulation by the intestinal lymphatic route. Almost all previous Oral capsules and tablets manufactured to increase testosterone are involved in the “first pass effect.” This renders the active compounds virtually useless.†

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Common Compounds:

There are a bunch of different compounds and different ways to stack them.

This guide will cover the following:

  • Well-known compounds and their other names
  • Possible Effects
  • Side effects
  • Stack-ability
  • Cycle lengths and types

*As with every product, results vary from person to person. Results are not guaranteed.*


1-Androsterone:

1-Andro To 1-Test

 

Other Names:
  • 1-Androsterone / 1-Andro
  • 1-DHEA / 1DHEA
  • 1-Dehydroepiandrosterone
  • 1-androstene-3b-ol-17-one
  • 3b-hydroxy-5a-androst-1-en-17-one
  • 3b-hydroxy-androst-1-ene-17-one
  • 3-hydroxy-5-androst-1-en-17-one
Popular Standalone Products:
Featured Blend Products:
Run Down:
  • Converts To 1-Testosterone†
  • Dry, Lean Muscle Mass Gains†
  • Increased Strength†
  • No Bloating/Estrogen Activity†
  • Good For Stacking†
  • Good For Cutting†
  • Increase Vascularity†

What Is 1-Andro?

1-Andro, also known as 1-DHEA, is a legal prohormone that undergoes a series of conversions within the body, eventually metabolizing into the active steroid 1-Testosterone. This conversion process involves the metabolization of 1-Andro into 1-testosterone (dihydroboldenone) and 1-androstenedione, both of which are positional isomers of testosterone and androstenedione. The subsequent conversion to dihydroboldenone is where the primary muscle-building benefits originate.†

What To Expect From 1-Andro:

1-Andro has been substantiated by research and is popular for its various benefits. Generally, it is effective in increasing lean muscle mass, enhancing strength, and boosting aggression, making it a sought-after supplement for both bulking and cutting phases.†

  • For bulking, products with higher concentrations of 1-Andro, such as 1-Testosterone, are recommended, potentially yielding faster results.†
  • Conversely, formulas like 1-AD may be better for cutting due to their slower breakdown. The label states it has 75mg of 1-Andro; it actually has 75mg of 1-Andro Decanoate, which yields 47 mg of 1-Andro. This is because of an additional ester chain, which helps regulate hormonal fluctuations.†

Additionally, it’s noteworthy that these products may contain supplementary ingredients. For instance, 1-Testosterone includes grapefruit extract, which slows the breakdown of 1-Andro, while 1-AD incorporates laxogenin, providing joint support and anabolic effects without hormonal effects. So if you’re unsure if you want to hop into the pro hormone game, laxogenin is another great option. Because it is a plant steroid, laxogenin isn’t hormonal. Women can also supplement it to improve strength, recovery, and joint pain. However, in this formula, you may only notice joint support from laxogenin.†

On the other hand, Chosen 1 from Blackstone Labs is a blend. This blend contains both esters and unesterified 1-Andro/1-DHEA. So it’s like getting the benefits of both 1-Testosterone and 1-AD, but at a much lower dose.†

Differences Between Hi-Tech 1-AD and 1-Testosterone:

  • Hi-Tech 1-AD: Converts to 1-Testosterone and is a milder hormone, providing cleaner gains and significant strength increases. It suits those seeking a balanced muscle gain and strength approach.†
  • Hi-Tech 1-Testosterone: 1-Testosterone, with its unique 1,2-double bond structure in the A ring (as opposed to the 4,5-double bond in standard testosterone), is metabolized differently. This slight modification means it cannot be converted to estrogen via aromatase nor into DHT, making it a stable molecule resistant to most traditional metabolism routes. It is often referred to as a “dry” compound, suitable for both cutting and bulking phases due to its strength benefits.†

1-Andro Side Effects:

As with any prohormone, users should be mindful of potential side effects. These may include acne, hair loss, prostate growth, cardiovascular issues, increased liver and kidney values, and testicular atrophy. Additionally, some individuals may experience low libido and lethargy, although these effects typically subside during post-cycle therapy (PCT).†

Because 1-Andro only affects androgenic receptors, the estrogenic side effects aren’t expected. Remember that side effects like acne and hair loss have a higher potential if you are already susceptible to them.†

Treating Side Effects:

We recommend taking an on-cycle support supplement like Gear Support. Products like this are going to help cut the potential for side effects. You would take it with your chosen pro hormones and stop during your PCT. You can try products like D-Aspartic Acid, Maca, Horny Goat Weed, or blends like Score! XXL for low libido.†

We encourage you to take a multivitamin with B Vitamins for your skin and hair care. You can also consider Fish Oil, Omega 3, or NAC, which benefits your whole body, hair, and skin. For acne prevention, you can try a ton of OTC cleansers; look for ones with salicylic acid and/or benzoyl peroxide.†

How To Cycle 1-Andro:

1-Andro is typically cycled for up to 8 weeks, followed by a 4-week PCT phase. Since each bottle generally covers a 4-week cycle, a second bottle is needed for an 8-week cycle.†


4-Androsterone:

4-Andro To Test

Other Names:
  • 4-Androsterone / 4-Andro
  • 4-DHEA / 4DHEA
  • 4-Dehydroepiandrosterone
  • 4-androstene-3b-ol-17-one
  • 3b-Hydroxy-4-androsten-17-one
  • 3β-hydroxyandrost-4-en-17-one
  • 3β-hydroxy-D4-androsten-17-one
Popular Standalone Products:
Featured Blend Products:
Run Down:
  • Converts To Testosterone†
  • Mass Gains†
  • Strength Gains†
  • Increased Sex Drive & Libido†
  • More Energy†
  • Helps Accelerate Muscle Recovery†
  • Supports Better Overall Mood†
  • Helps Reduce Muscle Fatigue†
  • Increases Protein Synthesis†

What Is 4-Andro?

4-Andro, also known as 4-DHEA, follows a similar conversion process to 1-Andro, undergoing a two-step transformation to become the target hormone. In the case of 4-Andro, this conversion leads to the production of testosterone. Initially, 4-DHEA converts to 4-androstenediol (4-adiol) before ultimately being metabolized into testosterone.†

What To Expect From 4-Andro:

Considered a ‘wet gainer,’ 4-Andro is associated with testosterone conversion, which may result in estrogen conversion and subsequent water retention. Consequently, users may experience substantial gains in muscle mass and strength. Due to the potential for water retention, 4-Andro is primarily recommended for bulking cycles, although it can be included in stacks for diverse objectives.†

Different products and dosages may yield varying effects. For instance, Blackstone’s Brutal 4ce blends 4-Andro, Hi-Tech’s Androdiol incorporates laxogenin, and LG’s 4 Andro comprises solely 4-Andro.†

What sets 4-Andro apart is its direct conversion to testosterone, bypassing intermediary precursors. This leads to accelerated gains, faster recovery, and a reduction in certain side effects associated with other prohormones like 1-Andro. Cycling with 4-Andro often enhances libido without inducing lethargy, offering users a heightened sense of vitality and well-being.†

Andro Side Effects:

Given the potential for estrogen conversion, users face the risk of related side effects, including water retention, fat gain, and gynecomastia. Additionally, common prohormone side effects such as acne, hair loss, cardiovascular issues, and aggression may occur. However, unlike methylated prohormones, 4-Andro is non-toxic to the liver.†

Treating Side Effects:

To mitigate estrogen-related risks, users may consider incorporating aromatase inhibitors (estrogen blockers) into their cycle or post-cycle therapy (PCT). These inhibitors help regulate estrogen conversion, minimizing the likelihood of adverse effects.†

For the other side effects, you can follow the same protocol as 1-Andro. NAC, Fish Oil, Multivitamins, and OTC acne cleansers. Because the 4-Andro is not methylated, you do not need to take on cycle support. However, you can take NAC or Milk Thistle if you still are concerned.†

How To Cycle 4-Andro:

Typically, 4-Andro is cycled for up to 8 weeks, followed by a 4-week PCT phase. Beginners may opt for shorter cycles (4 to 6 weeks) to assess their tolerance and response to the prohormone.†


19-Nor-4-Androstenediol:

19-NOR To Nan

 

 

Other Names:
  • 19-Nor-DHEA
  • 19-Nor-Andro
  • 19 NorAndrosterone
  • 19 Nor Dehydroepiandrosterone
  • NorAndrost-4-ene-3b-ol, 17-one
  • 19-Norandrost-4-ene-17-one
Popular Standalone Products:
Featured Blend Products:
Run Down:
  • Converts To Nandrolone†
  • Good For Stacking†
  • Increase Strength†
  • Dry, Lean Muscle Mass†
  • Supports Joint Health†
  • Boost Endurance†
  • Does Not Aromatize to Estrogen†
  • Does Not Convert to DHT†

What Is 19-Nor-DHEA?

19-Nor-4-Androstenediol, often referred to as 19-Nor-DHEA, operates differently than other discussed compounds, functioning more as a pre-prohormone. Through a two-step conversion process, 19-Nor-DHEA ultimately transforms into Nandrolone (Deca), a well-known anabolic compound.†

What To Expect From 19-Nor-DHEA:

Although extensive research is lacking, users have reported experiencing strength gains and lean muscle mass accrual with 19-Nor-DHEA. Results, however, may vary among individuals. This prohormone is particularly recommended for users susceptible to side effects, as Nandrolone generally exhibits milder effects compared to testosterone. Consequently, seasoned prohormone users may find its effects comparatively less pronounced.†

19-Nor-DHEA is generally favored by those seeking to simultaneously enhance muscle growth, strength, and fat loss. It is often regarded as suitable for individuals prioritizing strength gains, although it can also complement cutting stacks for physique-oriented goals.†

Notably, Blackstone Labs’ Abnormal features a blend formulation, while Hi-Tech’s Deca-Durabolin solely contains 19-Nor-DHEA.†

19-Nor-DHEA Side Effects:

With Nandrolone’s relatively mild nature, the risk of side effects is reduced compared to testosterone-based compounds. However, water retention and decreased libido have been reported among users, with 19-Nor-DHEA demonstrating a higher propensity for water retention than 4-Andro.†

Treating Side Effects:

To mitigate potential side effects, users may consider incorporating an estrogen blocker during their cycle. For libido support, supplements like D-Aspartic Acid, Maca, Horny Goat Weed, or blends such as Stamina Rx can be beneficial.†

Additionally, post-cycle therapy (PCT) is essential to restore natural testosterone levels. While on-cycle support is not mandatory, supplements like NAC or Milk Thistle may be taken for added liver support.†

How To Cycle 19-Nor-DHEA:

A typical cycle for 19-Nor-DHEA lasts up to 6 weeks, given its propensity to suppress natural testosterone production. Following the cycle, a 4-week PCT phase is essential for hormonal recovery. Beginners are advised to opt for shorter cycles to gauge their response to the prohormone and minimize potential risks.†


1,4-Androstadienedione:

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Other Names:
  • 1,4 AD
  • 1,4-Andro
  • 1, 4-androstadiene-3, 17-Dione
  • 1,4-Androstadienedione
Popular Standalone Products:
  • Equibolin, By Hi-Tech Pharmaceuticals ~ 75mg
Featured Blend Products:
Run Down:
  • Converts To Boldenone†
  • Dry, Lean Muscle Mass†
  • Improve Recovery Time†
  • Increases Strength†
  • Increases Appetite†
  • Boosts Energy†

What Is 1,4-Andro?

1,4-Androstadienedione, commonly called 1,4-AD, undergoes a two-step conversion process to reach its target hormone, boldenone. Boldenone, akin to testosterone but with an additional double bond, exhibits reduced affinity for enzymes responsible for estrogen conversion. This characteristic distinguishes it as a potent compound for lean muscle mass gains with minimal water retention.†

What To Expect From 1,4-Andro:

Notable for its ability to significantly increase hunger, Equipoise, containing 1,4-AD, is primarily recommended for bulking cycles. Alongside increasing appetite, users can anticipate gains in muscle mass and strength attributed to boldenone’s anabolic properties.†

Despite a low conversion rate to estrogen, 1,4-AD ensures relatively bloat-free cycles while still deriving benefits associated with estrogenic conversion. However, the effects of 1,4-Andro may manifest more gradually (typically 2-3 weeks) compared to other compounds.†

1,4-Andro Side Effects:

Due to its highly anabolic nature, the risk of side effects with 1,4-Andro is relatively low. However, Equibolin is recommended for more experienced users due to its potency.†

Treating Side Effects:

Supplementation with an estrogen blocker can aid in averting potential side effects associated with estrogen conversion. Additionally, on-cycle support supplements like NAC or Milk Thistle can be considered for individuals seeking an extra layer of protection.†

How To Cycle 1,4-Andro:

Results from 1,4-Andro supplementation typically become noticeable within 3-4 weeks, with cycles lasting up to 8 weeks followed by a 4-week PCT phase.†


Epiandrosterone:

EpiAndro to dht

Other Names:
  • 3-hydroxy-androstane-17-one
  • trans-Androsterone
  • Isoandrosterone
  • 3-Epiandrosterone
  • Epi-Andro
  • 3B-Hydroxy-5a-androstan-17-one
  • 5a-Androstan-3a-ol-17-one
  • 3Beta-hydroxy-5alpha-androstan-17-one azine
Popular Standalone Products:
Featured Blend Products:
Run Down:
  • Converts To DHT†
  • “Hardening Agent”†
  • Fat Loss†
  • Improve Recovery Time†
  • Increase Strength†
  • Support Libido†
  • Increase Vascularity†

What Is Epi-Andro?

Epiandrosterone, first identified in the 1930s, is a metabolite of DHEA (Dehydroepiandrosterone). While not the most potent androgenic compound, it holds significance as a popular cutting prohormone, known for promoting dry, lean muscle gains, enhancing vascularity, and boosting libido.†

What To Expect From Epi-Andro:

Epiandrosterone is popular for its efficacy in achieving dry, lean muscle gains, accompanied by increased vascularity and libido. Unlike some potent prohormones, Epiandrosterone is milder, yet it may induce acute stimulant effects, making it suitable for use as a pre-workout supplement. Notably, Epi Andro 50 by LG Sciences contains Epicatechin, a compound found in green tea and dark chocolate, which inhibits Myostatin production, thereby promoting muscle growth.†

Epi-Andro Side Effects:

Epiandrosterone does not aromatize into estrogen, reducing the likelihood of estrogen-related side effects. However, excessive conversion to DHT (Dihydrotestosterone) may occur, leading to hair-related issues, particularly in individuals predisposed to hair problems or male pattern baldness.†

Additionally, some users may experience joint discomfort during Epiandrosterone usage.†

Treating Side Effects:

While on-cycle support is not mandatory for Epiandrosterone, users seeking added protection may consider supplements like NAC, Milk Thistle, or specific on-cycle support products. Joint discomfort can be addressed using joint supplements such as Joint-RX. Users may consider Minoxidil for hair-loss-related issues.†

How To Cycle Epi-Andro:

Epiandrosterone cycles typically last up to six weeks to ensure optimal results without prolonged exposure. As effects may take time to manifest, longer cycles are recommended. Following the cycle, a 4-week PCT phase is advised to support hormonal balance and mitigate any potential adverse effects.†


HydroxyProgestins:

HydroxyProgestins

Other Names:
  • 5aOHP: 17beta {3ketoethyl}-androstane-3-one, 17a-ol 
  • 1,4-OHP: 17beta {3ketoethyl}-androsta-1,4-diene-3-one, 17a-ol
Popular Standalone Products:
Featured Blend Products:
Run Down:
  • Converts To DHT†
  • Dry, Lean Muscle Gains †
  • Strength Gains†
  • Increase Appetite †
  • Helps Accelerate Muscle Recovery†

What Are HydroxyProgestins?

HydroxyProgestins represent a novel class of prohormones known for their resemblance to 1-Testosterone or Boldenone, fostering muscle growth.†

What To Expect From HydroxyProgestins:

HydroxyProgestins, unlike DHEA prohormones, engage the enzyme 17,20 Lyase to facilitate their activity. This process cleaves the 17-position side chain, yielding an active steroid.†

(chemical name: 17beta-{1-Ketoethyl}-androstane-3-one, 17a-ol)

For instance, 5aOHP, an anabolic progestin, converts to stanolone or DHT. These compounds may act as natural myostatin inhibitors, elevate natural androgen levels, and augment transcription through increased messenger RNA activity. 5aOHP offers benefits akin to Winstrol, promoting a lean physique without the risk of hair loss commonly associated with Winstrol use.†

(chemical name: 17beta-{1-Ketoethyl}-androsta-1, 4-diene-3-one, 17a-ol)

On the other hand, 1,4-OHP serves as a precursor to boldenone, fostering appetite, aiding recovery, and contributing to lean mass gains without substantial water retention.†

HydroxyProgestin Side Effects:

HydroxyProgestins do not convert to estrogen or progesterone, mitigating associated side effects. However, supporting healthy liver function during or after the cycle is advisable.†

Treating Side Effects:

To bolster liver function, supplements such as Liver RX or Organ Shield can be beneficial. Additional support with NAC, Fish Oil, Multivitamins, and OTC acne cleansers may address other potential side effects.†

How To Cycle HydroxyProgestin:

A dosage range of 100-200 milligrams per day, split into two doses, is typically recommended. Short cycles spanning 3-4 weeks are preferred by many users to optimize results while minimizing potential risks.†


Dehydroepiandrosterone:

DHEA To Test

Other Names:
  • DHEA
  • Androstenolone
  • Prasterone
Popular Standalone Products:
Featured Blend Products:
Run Down:
  • Converts To Numerous Anabolic/Androgenic Hormones, Like Testosterone†
  • Could Slow Aging†
  • Improve Cognitive Function†
  • Improve Body Composition†
  • Boost Mood†
  • Improve Bone Density†

What Is DHEA?

DHEA is a naturally occurring hormone the adrenal glands produces, pivotal in testosterone and estrogen synthesis.†

What To Expect From DHEA:

DHEA supplementation is renowned for its potential to elevate testosterone and estrogen levels, making it a favored choice for anti-aging interventions and hormone replacement therapy. Beyond its role in hormone production, DHEA is implicated in various bodily functions, including immune response, metabolism, mood regulation, and cognitive function.†

In the realm of prohormones, DHEA derivatives like 1-DHEA and 4-DHEA are utilized to promote specific anabolic effects, such as muscle growth and strength enhancement.†

DHEA Side Effects:

While generally well-tolerated, DHEA supplementation may lead to minor side effects such as oily skin, acne, and increased hair growth in localized areas like the armpits and pubic region.†

Additionally, long-term use or excessive doses of DHEA may elevate testosterone and estrogen levels beyond optimal ranges, potentially contributing to adverse effects such as mood swings, cardiovascular complications, and hormonal imbalances.†

Treating Side Effects:

Given its primary role as a natural testosterone booster and anti-aging agent, additional on-cycle support is typically deemed unnecessary. However, individuals experiencing adverse effects should consider consulting a healthcare professional, especially if using DHEA for therapeutic purposes. Furthermore, periodic monitoring of hormone levels and adjusting supplementation regimens accordingly can help mitigate the risk of side effects.†

How To Cycle DHEA:

Although the impact of DHEA on younger populations has not been extensively studied, it is commonly recommended for older adults at doses ranging from 25-50mg per day. This regimen aims to capitalize on its potential benefits while mitigating the risk of adverse effects.†

Cycling protocols may vary depending on individual goals, health status, and response to supplementation, with some users opting for intermittent cycles or periodic breaks to prevent tolerance and maintain efficacy.†


3AD Dehydroandrosterol:

3AD to Test

Other Names:
  • 3AD
  • Dehydroandrosterol
  • Androst-5-ene-3a,17b-diol
  • 5-Androsten-3a,17b-diol
  • Androst-5-en-3a,17b-diol
  • 5-Androstenediol
Popular Standalone Products:
  • Mesotrope, by Dragon Pharma ~5 mg
  • 3-AD, by Enhanced Labs ~ 75mg
Featured Blend Products:
Run Down:
  • Increase Muscle Strength†
  • Dry, Hard Look†
  • May Boost Strength Of Other Compounds†

What Is 3AD?

3AD stands out from other prohormones due to its distinct biosynthesis pathway, which is not derived from dihydrotestosterone (DHT) metabolism but rather synthesized from DHA (dehydroandrosterone). This unique pathway contributes to its distinct mechanism of action, differentiating it from traditional prohormones.†

DHA Explained:

DHA, a naturally occurring androgenic corticoid compound, is primarily synthesized from dehydroandrosterone and other steroid precursors such as 5-androsten-3,17-dione. It exhibits anabolic, androgenic, anti-estrogenic, and anti-cortisol effects, making it a powerful component for muscle growth. DHA is estimated to have about 43% of the androgenic activity of testosterone, which allows it to increase lean muscle mass through nitrogen retention and enhanced protein synthesis.†

DHA is versatile, appearing in various forms such as esters, ethers, salts, and isomers, and can be sourced from animal steroids, plant sterols, or botanical extracts. Its supplementation, typically in capsule or powder form, promotes muscle growth by attaching to androgen receptors in muscle tissue, aiding in anabolic and anti-catabolic responses.†

What To Expect From 3AD:

Due to its unique origin and biosynthesis from DHA, 3AD is less likely to induce estrogenic effects compared to other prohormones. Users can expect potential benefits such as heightened muscle strength, lean muscle gains, and enhanced muscle hardness, making it a versatile option for both bulking and cutting cycles.†

Stacking 3AD:

For those aiming to bulk, 3AD can be effectively combined with compounds like DHEA, Androsterone, Epiandrosterone, or Arachidonic Acid to maximize muscle growth. For cutting, it pairs well with Epiandrosterone Acetate, Androsterone Acetate, or Arimistane to maintain muscle density while shedding fat.†

3AD Side Effects:

While generally well-tolerated, users may experience mild side effects such as acne and joint dryness, particularly during extended cycles.†

Treating Side Effects:

To mitigate the occurrence of acne and alleviate joint stiffness, individuals can adopt strategies similar to those recommended for other prohormones. This may include the use of topical acne treatments, joint supplements, and adherence to proper skincare routines to maintain skin health and hydration.†

How To Cycle 3AD:

Dosage recommendations for 3AD typically range between 25 and 60mg, with specific doses tailored to individual weight, experience level, and desired outcomes. Cycle lengths can safely span from 6 to 12 weeks, with breaks of at least 6 weeks between cycles to allow for adequate recovery and hormone normalization. While on-cycle support supplements may not be necessary for 3AD alone, they are advisable when stacking with other hormones to ensure comprehensive support and minimize potential side effects.†

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Post Cycle Therapy (PCT):

When concluding a prohormone cycle, it’s crucial to begin a Post Cycle Therapy (PCT) regimen to restore hormonal balance and safeguard your gains. During a cycle, exogenous hormones can disrupt the body’s natural production of testosterone and lead to an accumulation of estrogen, potentially resulting in undesirable side effects like fat gain, testicular atrophy, and lethargy.† Need more information on PCTs? Check out our new guide HERE!

Here’s what you need to know about PCT and some popular products to consider:

  1. Testosterone Restoration: After a cycle, natural testosterone levels plummet, while estrogen levels may remain elevated. PCT aims to kickstart the body’s testosterone production to mitigate the risk of muscle loss and other negative effects associated with low testosterone levels.†
  2. Estrogen Modulation: Excess estrogen can lead to gynecomastia (enlargement of male breast tissue) and water retention. PCT includes compounds that help regulate estrogen levels, preventing these unwanted effects.†
  3. Liver Protection: Many prohormones exert stress on the liver and kidneys. PCT products often contain ingredients that support liver function, aiding in detoxification and metabolic processes.†

What to look for in a PCT:

  • Testosterone repair: Look for ingredients like D-Aspartic Acid, Tribulus Terrestris, and Fenugreek Extract, which are known for their ability to stimulate natural testosterone production.†
  • Estrogen modulation:  Compounds such as Arimistane (Androsta-3,5-diene-7,17-dione) help regulate estrogen levels and prevent estrogen-related side effects.†
  • Liver Protection: Ingredients like Milk Thistle, NAC, and TUDCA support liver health and aid in detoxification.†

Popular products:

  • Novedex XT, By Gaspari Nutrition: Known for its potent estrogen-blocking properties, Novedex XT helps restore hormonal balance post-cycle.†
  • Arimistane, By Hi-Tech Pharmaceuticals: Arimistane is a powerful aromatase inhibitor that prevents the conversion of testosterone to estrogen, aiding in estrogen regulation.†
  • Estrogenex, By Hi-Tech Pharmaceuticals: This comprehensive formula contains estrogen-modulating ingredients to prevent estrogen-related side effects while supporting natural testosterone production.†
  • PCT V, Blackstone Labs: PCT V is designed to support testosterone production and restore hormonal balance after a prohormone cycle.†
  • Letro XT™, Blackstone Labs: Letro XT™ contains 3b-hydroxy-androsta-1,4,6-triene-17-one and 3b-hydroxy-androsta-4,6-diene-17-one, which can help reduce estrogen and support natural production of testosterone.†
  • HellRaiser™ PCT, Innovative Labs: This PCT supplement contains a blend of ingredients to support testosterone production, regulate estrogen, and promote overall hormonal balance.†

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Prohormone Stacks:

Prohormones can be cycled individually or combined into stacks to achieve specific goals, such as bulking, cutting, or increasing strength. For example, the Blast Your Mass Stack features 1-Testosteone and Equipoise (formally Equibolin).

hi-tech_pharmaceuticals_blast_your_mass_stack

Considerations for Stacking:

  1. Experience with Prohormones: Beginners may opt for single prohormone cycles or pre-made blends for simplicity, like Helladrol or Monster Plexx, while more experienced users may prefer customized stacks for targeted results. Or, for more customization, you can try the Hi Tech Prohormone + Laxogenin Stack or First Time Cycle – Blackstone Labs Prohormone Stack.†
  2. Time: Stacking multiple prohormones can require longer cycles and may necessitate more comprehensive post-cycle therapy (PCT) protocols.
  3. Preference: Some users prefer the convenience of pre-made stacks, while others enjoy the flexibility of creating their own combinations based on their specific goals.
  4. Finances: Stacking multiple prohormones can be more expensive than using a single compound, so budget considerations may influence stacking decisions.

We recommend a couple of different stack options, such as the Hi-Tech Pharmaceuticals ProHormone Stack, for more intermediate pro hormone users.

  • Bulking : 1-Andro + 4-Andro
  • Cutting: 1-Andro + 19-Nor-DHEA
  • Strength: 19-Nor-DHEA + 1,4 Andro

Dosing Recommendations:

  • Follow the directions on the product labels for dosing instructions. Typically, prohormones are taken orally with meals, and doses may be split throughout the day.
  • If a bottle recommends taking 2-4 tablets per day, you can divide the dosage, taking 1-2 tablets in the morning and 1-2 tablets in the evening.

If you prefer an all-in-one type of pro hormones, an intermediate pro hormone user could also benefit from the abovementioned products. Or you could try products like Halodrol and Metha Quad Extreme.


For more advanced pro hormone users:

We have stacks already listed that you can purchase with all the items and PCT together.

Bulking Stacks
Cutting Stacks:
Strength Stacks:
PCT Stacks:

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Pro hormone Blends:

In addition to individual prohormones, prohormone blends offer unique compound combinations to target specific goals. Here’s a closer look at popular blends:

Anavar:Anavar Supplement Facts

Anavar is a popular prohormone blend known for stimulating ATP production in muscle cells, improving energy levels, and enhancing workout performance.† Here are some key benefits associated with Anavar:

  • Increased ATP Production: Anavar helps stimulate and drive ATP (adenosine triphosphate) into muscle cells, providing a sustained energy source during intense physical activity. This can lead to improvements in endurance and workout performance.†
  • Enhanced Recovery Times: Anavar may contribute to faster recovery times between workouts by supporting ATP production and optimizing energy metabolism.† 
  • Muscle Volume and Size: Anavar may increase muscle volume and size by increasing protein synthesis and nitrogen retention within muscle tissues. This can result in fuller, more defined muscles with continued use.†
  • Improved Strength: With its capacity to enhance ATP production and support muscle growth, Anavar can also improve overall strength and power output.† 

How To Use Anavar By Hi-Tech Pharmaceuticals:

The manufacturer recommends taking three (3) tablets in the morning and three (3) tablets in the afternoon or evening. Do not exceed the recommended dosage, as Anavar is a potent anabolic agent.

Anavar Review By James: “Fast delivery Anavar is a good product I always order at least too cycle of this stuff because i know it work i generally order off of suppz bit this time i got it from same day supplement because the price was too good and the shipping was free thank you same day supplement”

Dianabol:Dianabol Supplement Facts

Dianabol is a prohormone blend popular for promoting lean muscle growth while preserving existing muscle mass and strength.† Here are some key benefits associated with Dianabol:

  • Lean Muscle Building: Dianabol is highly effective at promoting lean muscle gains due to its anabolic properties.†
  • Preservation of Muscle Mass: Besides promoting muscle growth, Dianabol also helps preserve existing muscle mass.† 
  • Enhanced Strength: Dianabol is known for enhancing strength and power output, making it a popular choice among athletes and bodybuilders seeking to improve performance. Users often experience significant lifting capacity and overall strength increases while using Dianabol.†
  • Improved Recovery: Dianabol can help users train more frequently and with greater intensity by reducing muscle damage and promoting faster recovery between workouts.†

How To Use Dianabol By Hi-Tech Pharmaceuticals:

The manufacturer recommends taking one (1) tablet three times daily with meals. This is important as the strength of this product can cause nausea if consumed without eating.

Dianabol Review By N/A : “First the basics…getting older is not a death sentence! After back surgery, started weight training and after great gains, at six months tried this product on the advice of a friend. Now about 10 days in and seeing results that, frankly, I didn’t expect at this age…more energy during my workouts, harder and thicker muscles and as an added bonus… significant lift to my libido which wasn’t even a problem…lol. Timely, fast delivery, good pricing structure and results…definitely will be a repeat buyer.”

Superdrol:Superdrol Supplement Facts

Superdrol is a potent prohormone known for its ability to promote lean muscle growth, enhance muscle hardness, increase strength, and improve overall body composition.† Here are some key benefits associated with Superdrol:

  • Lean Muscle Growth: Superdrol is highly effective at stimulating lean muscle growth.†
  • Muscle Hardness: One of the stand-out characteristics of Superdrol is its ability to enhance muscle hardness and definition.† 
  • Increased Strength: Superdrol is popular for its strength-enhancing properties, allowing users to lift heavier weights and perform more intense workouts.† 

How To Use Superdrol By Hi-Tech Pharmaceuticals:

The manufacturer recommends taking one (1) tablet in the morning and one (1) tablet in the evening. Do not exceed two (2) per day.

Superdrol Review By Steven: “I took Superdrol for about a month. I’m 68! I saw results. I’m taking it again, for 2 months this time, along with Decabolin. Definitely helps add muscle.”

Winstrol:Winstrol Supplement Facts

Winstrol is a popular product known for its ability to promote various benefits related to muscle growth, strength, and physical appearance.† Here are some key benefits associated with Winstrol:

  • Increase Lean Muscle Mass: Winstrol supports lean muscle mass gains without excessive water retention or bloating.†
  • Boost Strength: It is popular for its strength-enhancing properties, making it a popular choice among athletes and bodybuilders looking to improve their performance.† 
  • Increase Hardness and Vascularity: One of the stand-out features of Winstrol is its ability to enhance muscle hardness and vascularity. Users often experience a more defined appearance, with muscles appearing harder, denser, and more vascular.† 

How To Use Winstrol By Hi-Tech Pharmaceuticals:

The manufacturer recommends taking one (1) tablet three times per day. Do not take more than four (4) tablets daily.

Winstrol Review By Daniel: “Felt the product working only after a few days and felt no side effects even after two weeks. Fantastic pump and strength gains.”

Sustanon 250:

Sustanon Supplement Facts

Sustanon 250 comprises a unique blend of testosterone esters, each contributing to its array of benefits:

  • Lean Muscle Gains: The presence of 4 androstene-3b-ol,17-one Propionate, 4 androstene-3b-ol,17-one Enanthate, 4 androstene-3b-ol,17-one Isocaproate, and 4 androstene-3b-ol,17-one Decanoate facilitates optimal muscle protein synthesis. This leads to significant gains in lean muscle mass, promoting a sculpted and well-defined physique.†
  • Strength Enhancement: Sustanon 250 enhances strength levels by incorporating these testosterone esters. This blend contributes to muscular power and endurance improvements, allowing individuals to push their limits during workouts and achieve greater strength gains over time.†
  • Increased Libido: The balanced combination of testosterone derivatives supports healthy libido and sexual function. Users may experience heightened sexual desire and improved performance due to the positive impact of Sustanon 250 on testosterone levels.†
  • Elevated Energy Levels: Sustanon 250’s composition fosters enhanced energy metabolism, increasing users’ vitality and stamina. This surge in energy helps individuals sustain intense training sessions and remain active throughout the day, leading to improved overall performance.†

How To Use Sustanon 250 By Hi-Tech Pharmaceuticals:

The manufacturer recommends taking one (1) tablet daily. Do not exceed two (2) tablets daily.

Sustanon 250 Review By A.D.: “Was a bit skeptical about this product’s claims. I was hoping for a mild bump. What I got was the closest results to being on without being on. Strength went through the roof by the second week and kept getting better as the cycle continued. Recovery was absolutely amazing as well. Now here’s where it gets even better, strength gains have stayed with me now three weeks post cycle. Will be back for more of this!”

Halodrol:

Halodrol Supplement FactsHalodrol offers a comprehensive range of benefits tailored to support muscle growth and overall performance:

  • Increased Strength: Halodrol may enhance muscular strength, enabling users to lift heavier weights and perform more intense resistance exercises.† 
  • Improved Recovery: By promoting faster recovery between workouts, Halodrol aids in reducing muscle fatigue and soreness. This allows individuals to maintain consistent training regimens, optimize muscle repair processes, and minimize the risk of overtraining-related injuries, ultimately supporting long-term progress and performance.†
  • Increased Energy: Halodrol’s unique blend of ingredients helps boost energy levels, providing users with the stamina and endurance needed to tackle demanding workouts effectively.† 
  • Lean Muscle Mass: Halodrol is specifically formulated to promote the development of lean muscle mass while minimizing unwanted fat accumulation.†
  • Libido Support: Halodrol’s testosterone-boosting properties can positively impact libido and sexual function.†

How To Use Halodrol By Hi-Tech Pharmaceuticals:

The manufacturer recommends one (1) tablet 30 minutes prior to training. On non-training days, take one (1) tablet in the morning or afternoon. Do not exceed two (2) per day.

Halodrol Review By Mikey: “Quality Product. My overall experience has been tremendous.”

Primobolan:Primobolan Supplement Facts

Primobolan harnesses the power of its ingredients to deliver a range of benefits tailored to support muscle growth and performance:

  • Increase Lean Muscle Mass: Primobolan’s formula, enriched with 1-Androstene-3b-ol-17-one, is designed to stimulate the development of lean muscle tissue.†
  • Improve Strength: Including 1-Androstene-3b-ol-17-one, Primobolan enhances muscular strength, enabling users to lift heavier weights and perform more intense workouts.†
  • Enhanced Vascularity: The presence of 3B-Acetoxyandrost-5-en-17-one in Primobolan promotes enhanced vascularity, resulting in visibly improved blood flow and circulation. This may lead to a more pronounced vascular appearance, characterized by increased vein prominence and muscle definition, enhancing overall aesthetics.†
  • Increased Protein Synthesis: Primobolan’s formula, including 6-keto-(25R)-spirost-5-en-3beta-diol, supports enhanced protein synthesis, facilitating the efficient utilization of dietary proteins for muscle repair and growth. This promotes accelerated recovery between workouts and supports optimal muscle tissue regeneration, enabling users to maximize their training results.†
  • Improved Exercise Performance: The presence of 6-keto-(25R)-spirost-5-en-3beta-diol in Primobolan may improve exercise performance by enhancing energy metabolism and endurance. This allows individuals to sustain high-intensity workouts for longer durations, increasing training volume and performance gains.†

How To Use Primobolan By Hi-Tech Pharmaceuticals:

The manufacturer recommends one (1) tablet three times per day. Do not take more than six (6) tablets daily.

Primobolan Review By Mary: “My brother is a pharmacist and recommended this for an intense workout and he is right! I am energized, focused and feel good after. I recommend this too.”

Halotestin:

Halotestin Supplement Facts

Halotestin is formulated with potent ingredients to deliver a range of performance-enhancing benefits tailored to support strength, muscle density, and libido:

  • Increase Strength & Power: Halotestin’s blend of ingredients, including 17beta (3ketoethyl)-androstane-3-one, 17a-ol at 10mg, supports significant increases in strength and power output. By promoting anabolic processes within the body, it enhances muscular strength and performance, enabling users to achieve new personal bests in their training endeavors.†
  • Improves Muscle Density: With 4-androsten-3B-ol-17-one at 50 mg, Halotestin improves muscle density, resulting in a more defined and sculpted physique. This ingredient aids in developing lean muscle mass while reducing excess body fat, leading to increased muscle definition.†
  • Enhanced Libido: Halotestin’s formula, featuring 3B-Hydroxyetioallocholan-17-one at 75 mg, may contribute to increased libido and sexual function. Optimizing hormone levels and promoting hormonal balance supports healthy libido levels, enhancing overall sexual performance and satisfaction.†

How To Use Halotestin By Hi-Tech Pharmaceuticals:

The manufacturer recommends taking one (1) tablet in the morning and one (1) tablet in the afternoon.

Halotestin Review By Trent: “My strength and size has been consistently going up week by week, while using Halotestin. My bench, squat and deadlift are consistently going up. I help but to believe Halotestin is doing wonders!”

Trenabol:

Trenabol Supplement Facts (1)

 Often compared to trenbolone, Trenabol is crafted with powerful ingredients to enhance the growth of lean muscle mass, strength gains, and a dry, defined physique:

  • Increase Lean Muscle Mass: Trenabol features 3b-enanthoxy-19-nor-androst-4-ene-17-one at 76mg, a potent compound that stimulates lean muscle growth. By supporting anabolic processes within the body, this ingredient supports the development of dense muscle tissue, contributing to a more sculpted and muscular physique.†
  • Boost Strength: With its unique formulation, Trenabol enhances strength levels, enabling users to push through plateaus and achieve new heights in their training performance. By optimizing muscle function and promoting efficient energy utilization, Trenabol helps individuals lift heavier weights and maximize their strength potential.†
  • Zero Water Retention: Unlike some prohormones that may cause water retention, Trenabol’s formula may provide dry, lean gains without unwanted bloating or puffiness. This is particularly beneficial for individuals seeking a defined appearance, as it helps to minimize water retention, revealing the full extent of their muscular definition.†

Trenabol vs. Trenbolone:

While Trenabol shares similarities with trenbolone in terms of its effects on muscle growth and performance enhancement, there are notable differences between the two†:

  1. Legality: Trenbolone is a controlled substance and is classified as an illegal anabolic steroid in many countries, including the United States. In contrast, Trenabol is available as a prohormone supplement. Which offers a legal alternative for individuals seeking similar benefits without the legal risks associated with illicit steroid use.†
  2. Formulation: Trenabol is a prohormone containing precursor compounds that convert to active hormones within the body. In contrast, trenbolone is a synthetic anabolic steroid designed to mimic the effects of testosterone, with a much higher potency and direct activity on androgen receptors.†
  3. Side Effects: While both can produce similar effects on muscle growth and performance, trenbolone is associated with a higher risk of side effects due to its potent androgenic properties. These side effects may include androgenic effects such as acne, hair loss, and prostate enlargement, as well as cardiovascular risks and suppression of natural testosterone production. Trenabol, on the other hand, may offer a potentially safer alternative with a reduced risk of adverse effects, although individual responses may vary.†

How To Use Trenabol By Hi-Tech Pharmaceuticals:

The manufacturer recommends taking one (1) tablet in the morning and one (1) tablet in the evening. Do not exceed two tablets daily.

Trenabol Review By Jake: “Strength has gone up while my weight has gone down. Definitely seeing the most definition I have ever had.”


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Wrapping Up!

This concludes our guide on popular prohormone compounds! Thank you for reading, and if there’s another product you’d like us to review, an ingredient that you think needs further elaboration or another blog idea you want to see in the future– send us an email here!

Check out some of our other blogs!

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Prohormone Safety:

Ensuring the safety of pro hormone use is essential, and there are several key steps individuals should take to minimize risks:

  1. Pre-Cycle Blood Work:
    Before starting a pro hormone cycle, comprehensive blood work is essential to establish baseline levels of key biomarkers, including testosterone, estrogen, liver enzymes, and lipid profiles. This baseline data serves as a reference point for monitoring changes throughout the cycle and allows for early detection of any adverse effects.†
  2. Consultation with a Physician:
    A medical professional can assess health status, evaluate potential risks, and provide personalized guidance on pro hormone use based on medical history, current health conditions, and other relevant factors.†
  3. Monitoring Effects:
    Throughout the pro hormone cycle, diligent monitoring of the effects is crucial. This includes observing changes in muscle mass, strength, libido, mood, and energy levels, as well as any adverse reactions such as acne, hair loss, or cardiovascular symptoms. Keeping a detailed log of symptoms and progress can aid in the early detection of issues and informed decision-making.†
  4. Adherence to Dosage and Cycling Protocols:
    Following recommendations on dosage and cycling protocols is essential for minimizing risks associated with pro hormone use. †
  5. Post-Cycle Therapy (PCT):
    Implementing a comprehensive PCT regimen is vital for restoring natural hormonal balance and mitigating potential side effects following the end of a pro hormone cycle. †

Warnings And Side Effects:

Hi-Tech Pharmaceuticals:

Like any prohormone, we suggest that you be over 21, have a good diet and exercise program, and be in good general health, as checked by a doctor. Keep out of reach of children. Do not use if governed by any governing body that prohibits prohormone use.

This product should not be used in place of or as a substitute for recommendations by your doctor. This product may cause false positives on urine tests for competitive athletes. Please check with your regulatory body before taking this product.

No clinical study has been performed on Dymethazine.


Blackstone Labs:

KEEP OUT OF THE REACH OF CHILDREN. NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. Consult a physician before using this product. Do not exceed recommended serving. Exceeding recommended serving of Chosen 1 may cause serious adverse health effects. Stop using if you experience adverse effects. Possible side effects include:

  • Acne
  • Hair loss
  • Hair growth on the face (in women)
  • Aggressiveness
  • Irritability
  • Increased levels of estrogen  

Important:

Do not use if governed by anybody that prohibits hormone use. Chosen 1 contains steroid hormones. This may cause increased facial and body hair, voice deepening. If you are at risk for prostate or breast cancer, you should not use Chosen 1.

Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of:

  • Prostate cancer
  • Prostate enlargement
  • Heart disease
  • Low “good” cholesterol (HDL)
  • Are you using other dietary supplements
  • Are you taking prescription medications
  • Taking any over-the-counter drugs

Do not exceed the recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects (Brutal 4ce, AbNORmal) include:

  • Acne
  • Hair loss
  • Hair growth on the face (in women)
  • Aggressiveness
  • Irritability
  • Increased levels of estrogen

Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heart rate, dizziness, blurred vision, or other similar symptoms. This product contains steroid hormones that may cause increased facial and body hair and voice deepening. You should not use this product if you are at risk for prostate or breast cancer. Do not use if governed by any body that prohibits hormone use.

This product contains ingredients that may be banned by some sports organizations and/or increase the risk of a false positive on a drug test. Please consult with your sports organization or physician before taking this product.

ALLERGEN WARNING: Manufactured on shared equipment that also processes Eggs, Wheat, and Soy (Lecithin).


LG Science:

Keep out of reach of children. Not for use by individuals under the age of 21 years.  Do not use if governed by any governing body that prohibits prohormone use.  This product should not be used in place of or as a substitute for recommendations by your doctor. No clinical study has been performed on Anavar.

This product contains ingredients that may be banned by some sports organizations and/or increase the risk of false positives on a drug test. Please consult with your sports organization or physician before taking this product.

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Disclaimer:

†PLEASE NOTE: The intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While our goal is to maintain and display accurate information, we can’t guarantee it represents the latest product formulation or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the views and information the manufacturers and users provide. The Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent any disease or illness.

References:

Talib Ahmad Supplement Expert

Talib has been a supplement and fitness enthusiast for over 10 years. He is a passionate powerlifter who enjoys helping others with their supplement regimens and training programs to ensure they achieve the best performance for their goals.

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