What Is Irisin? The ‘Exercise Hormone’ Explained and How Supplements May Help

September 17, 2024 Talib Ahmad Supplement Expert 177 Views

Have you ever wished there was a way to get more out of your workouts without spending extra hours in the gym? Imagine if there were a hormone that could help you burn fat, build muscle, and boost your metabolism—all from the comfort of your own home. Enter irisin, a fascinating hormone that’s often called the “exercise hormone” because of its incredible benefits linked to physical activity.

Discovered relatively recently, irisin is released during exercise and is crucial in converting stubborn fat into energy-burning “brown fat.” But what if you could support this process even when you’re not working out? In this blog, we’ll dive into what irisin is and how it works in your body and explore how certain supplements might help you make the most of this powerful hormone.

What Is Irisin?

Irisin might sound like a complex term, but it’s a fascinating hormone that greatly impacts how your body handles exercise. Discovered in 2012 by researchers led by Dr. Bruce Spiegelman, irisin is often dubbed the “exercise hormone” because it’s released during physical activity and helps your body convert fat into energy. (1)

So, how does irisin work its magic? Here’s a simple breakdown:

The Role of Irisin: When you exercise, especially during aerobic activities like running or cycling, your muscles release irisin into the bloodstream. This hormone then travels to fat cells, where it does something quite remarkable—it helps convert white fat, which stores energy, into brown fat, which burns energy. This conversion is crucial because brown fat is known for its ability to burn calories and generate heat, making it a key player in weight management and metabolism. (2,3)
How Irisin Affects Your Body: Think of irisin as a natural fat-burning boost. By promoting the creation of brown fat, irisin helps increase your overall calorie burn, even when you’re at rest. It also plays a role in muscle maintenance and recovery by supporting muscle metabolism and growth. Essentially, irisin helps you get more benefits from your workouts and supports your body in staying fit and healthy. (3,4)

Benefits Of Irisin:

Irisin isn’t just an interesting hormone—it’s a powerful player in your health and well-being. While its most well-known benefits are tied to exercise and fat burning, irisin also has potential advantages in other areas of health. Let’s explore some of the key benefits of irisin:

1. Fat Burning and Weight Loss:

One of the standout benefits of irisin is its ability to help burn fat. When you exercise, irisin is released into your bloodstream and signals fat cells to convert from white fat (which stores energy) into brown fat (which burns energy). Brown fat helps increase your overall calorie burn, even when resting. This can lead to more effective weight management and reduced stubborn body fat. Essentially, irisin helps you get more out of your workouts and supports a healthier body composition. (3,4)

2. Muscle Strength and Recovery:

Irisin plays a significant role in maintaining and enhancing muscle health. During exercise, it helps your muscles adapt and recover by supporting muscle metabolism and growth. This can lead to improved muscle strength and endurance over time. By promoting efficient muscle repair, irisin can also help reduce soreness and accelerate recovery after intense workouts. (4,5,6)

3. Metabolism Boost:

Beyond fat burning, irisin contributes to a boosted metabolism. This means your body becomes more efficient at processing and utilizing nutrients. A higher metabolism can lead to better energy levels and help manage weight. Even on days when you’re not exercising, elevated irisin levels can help keep your metabolism active. (4,7)

4. Anti-Aging Effects:

It plays a role in transforming white fat into brown fat, which helps boost metabolism and prevent age-related weight gain. Research has shown that higher levels of irisin improve glucose regulation and reduce insulin resistance, helping to manage obesity, which is common as we age. Additionally, irisin has anti-inflammatory properties that counteract the inflammation associated with aging. This can support overall cellular health and potentially slow down some aspects of the aging process. (8,9)

5. Joint Health:

Irisin may benefit joint health by reducing inflammation and improving mobility. It promotes physical activity and helps manage body fat, decreasing stress on joints and enhancing joint function. Studies also suggest low irisin levels are linked to bone problems like fractures and osteoporosis. Irisin supports bone health by reducing inflammation and promoting bone formation. It helps protect cartilage and bone cells, aiding in conditions such as osteoarthritis and speeding up bone fracture healing. While more research is needed to fully understand its effects, irisin positively maintains joint and bone health. (2,6,10)

6. Heart Health:

The connection between irisin and heart health is an exciting area of research. Some studies suggest that irisin may have protective effects on the cardiovascular system. By improving metabolic health and reducing fat, irisin may contribute to lower blood pressure and a healthier heart. Its role in reducing inflammation and supporting overall cardiovascular function makes it a valuable hormone for heart health. (3,5,11,12)

7. Cognitive Function and Mental Health:

Preliminary evidence suggests irisin could benefit brain health and mental well-being. Some studies have linked it to improvements in cognitive function and a reduction in symptoms of depression and anxiety. In terms of brain health, irisin helps enhance cognitive function. It supports the production of brain-derived neurotrophic factor (BDNF), which is essential for memory and learning. By reducing neuroinflammation, irisin may also protect against cognitive decline and conditions like dementia. (8,9,13,14)

8. Blood Sugar Regulation:

Irisin may also play a role in regulating blood sugar levels. By enhancing metabolic function and insulin sensitivity, irisin helps your body manage blood glucose more effectively. This can be particularly beneficial for preventing or managing type 2 diabetes and maintaining overall metabolic health. (15,16,17)

In summary, irisin offers a range of benefits beyond just enhancing the effects of exercise. From supporting fat burning and muscle recovery to potentially aiding in anti-aging, joint health, and heart health, this hormone plays a versatile role in maintaining a healthy, active lifestyle. As research continues, we may uncover even more ways that irisin contributes to our overall well-being.†

How To Boost It Naturally:

Boosting irisin doesn’t require a magic pill or extreme measures—there are several natural and effective ways to enhance your irisin levels and maximize its benefits. Here’s how you can naturally increase your irisin production through exercise, diet, and lifestyle changes:

1. Engage in Regular Exercise:

Aerobic Exercise: Running, swimming, and cycling are excellent for increasing irisin levels. These exercises boost your heart rate and stimulate irisin release from your muscles. (18)
High-Intensity Interval Training (HIIT): HIIT involves short bursts of intense exercise followed by brief rest periods. This type of workout is particularly effective for increasing irisin levels and enhancing fat burning. (19)
Strength Training: Lifting weights and doing resistance exercises help build muscle and support irisin release. Combine strength training with aerobic exercise for a well-rounded fitness regimen. (20)

2. Focus on a Balanced Diet:

Protein-Rich Foods: Adequate protein consumption supports muscle growth and recovery and enhances irisin production. (21)
Healthy Fats: Omega-3 fatty acids in fish, flaxseeds, and walnuts can support overall metabolic health and may help optimize irisin levels. (22)

3. Get Enough Quality Sleep:

Adequate Sleep: Good sleep supports overall health and helps regulate hormones, including irisin. Poor sleep can negatively impact your metabolism and hormone balance. (23,24)

4. Manage Stress:

Stress Reduction Techniques: Chronic stress can negatively affect hormone levels and overall health. (25,26)

5. Stay Hydrated:

Drink Plenty of Water: Proper hydration is essential for maintaining metabolic function and supporting overall health. (27)

Incorporating these strategies into your daily routine can help you naturally boost irisin levels, enhance overall health, and maximize your fitness efforts.†

Can Supplements Help?

While regular exercise and a healthy lifestyle are key to boosting irisin levels, you might be wondering if supplements can offer additional support. Although direct irisin supplements are not yet available, several other supplements can potentially enhance your irisin levels or support similar metabolic and fitness benefits. Here’s a look at some supplements that might help:

Carnitine
Resveratrol
Omega-3 Fatty Acids
Caffeine
Vitamin D
Taurine
Ursolic Acid
Gynostemma
Hesperidin

1. L-Carnitine:

L-carnitine is a popular supplement known for its role in fat metabolism and energy production. It is often used to support weight loss and enhance athletic performance. (28)

How L-Carnitine Works: L-carnitine helps transport fatty acids into the mitochondria, the energy powerhouses of cells, where they are burned for fuel. This process not only aids in fat loss but also boosts overall energy levels. By enhancing fatty acid oxidation, L-carnitine can help reduce fat accumulation, which is beneficial for managing body weight and improving metabolic health. (28)

Synergistic Effects: Supplementing with L-carnitine may complement the effects of irisin by boosting fat metabolism and improving exercise performance. In the study, participants who took L-carnitine supplements alongside exercise experienced a notable boost in irisin levels compared to those who did not. This indicates that L-carnitine may help enhance the body’s natural response to exercise by increasing irisin levels, improving fat metabolism and overall metabolic health. (29)

2. Resveratrol:

Resveratrol is a natural compound found in red wine, grapes, and certain berries, and it is known for its antioxidant and anti-inflammatory properties. It has gained popularity as a supplement for its potential health benefits, including its effects on aging and metabolism. (30)

How Resveratrol Works: Resveratrol is known for its antioxidant and anti-inflammatory properties. It influences various metabolic pathways, including activating sirtuins, particularly SIRT1. SIRT1 is crucial in regulating metabolism, glucose homeostasis, and fat storage. By activating SIRT1, resveratrol can help enhance energy expenditure and metabolic function. (31,32)

Synergistic Effects: When combined with exercise, resveratrol’s effects on irisin levels and metabolic health are further enhanced. In a clinical trial, resveratrol was found to increase FNDC5 levels, which suggests that it can boost irisin production. This increase in FNDC5 leads to greater activation of brown fat, which enhances calorie burning and improves insulin sensitivity. The positive impact on FNDC5 and SIRT1 indicates that resveratrol helps stimulate processes similar to exercise-induced, promoting better fat metabolism and metabolic health. (31,32)

3. Omega-3 Fatty Acids:

Omega-3 fatty acids, commonly found in fish oil and flaxseeds, are known for their numerous health benefits, including supporting heart health and reducing inflammation. (33)

How Omega-3 Fatty Acids Work: Omega-3 fatty acids are essential fats that support cellular function, reduce inflammation, and improve cardiovascular health. They have been shown to influence fat metabolism and insulin sensitivity, making them beneficial for managing weight and metabolic disorders. (33)

Synergistic Effects: In a study where participants took omega-3 supplements along with combined exercises, the group receiving omega-3s showed a notable increase in serum irisin levels compared to those who did not. This effect was observed when omega-3s were combined with exercise, indicating that omega-3s can enhance the body’s response to physical activity and improve overall metabolic health. (29)

4. Caffeine:

Caffeine, a well-known stimulant in coffee, tea, and various energy drinks, is famous for boosting alertness and improving physical performance. (34)

How Caffeine Works: Caffeine stimulates the central nervous system, increases energy levels, and enhances physical performance. It does this by blocking adenosine receptors in the brain, which can reduce fatigue and improve focus. Additionally, when we exercise, our muscles release calcium ions, activating cell signals. Caffeine mimics this process, increasing calcium levels and activating pathways that boost irisin production. (34)

Synergistic Effects: Supplementing with caffeine might enhance the benefits of Irisin, a protein that promotes fat burning. Caffeine boosts overall metabolic activity and can improve your exercise performance, making workouts more effective. It also stimulates fat metabolism by increasing the release of fatty acids into the bloodstream, which your body can then use for energy. Recent research indicates that caffeine can elevate Irisin levels, potentially amplifying its fat-burning effects and helping you achieve better results from both exercise and fat loss efforts. (34)

5. Vitamin D:

Vitamin D is an essential nutrient known for its role in maintaining bone health and supporting immune function. Found in foods like fatty fish, fortified dairy products, and through sun exposure, vitamin D is crucial for overall health. (35)

How Vitamin D Works: Vitamin D regulates calcium and phosphorus in the body, which are essential for maintaining strong bones and a well-functioning immune system. It also plays a role in muscle function and has been linked to better overall metabolic health. Adequate vitamin D levels can enhance mood and energy and even assist with weight management. (35)

Synergistic Effects: Emerging research highlights the potential synergy between vitamin D and irisin, a protein involved in energy homeostasis and fat metabolism. Recent studies have demonstrated that vitamin D supplementation can increase irisin levels, particularly in conditions of low vitamin D. For instance, a six-month vitamin D treatment in individuals with hypovitaminosis D significantly boosted irisin serum levels. This effect was confirmed in lab experiments, where vitamin D increased the expression of Fndc5, the precursor to irisin, in muscle cells. (36,37,38)

Moreover, vitamin D appears to work by enhancing the expression of key proteins like Sirt1 and PGC1α, which are crucial for mitochondrial function and muscle health. These proteins help regulate energy use and muscle development, potentially amplifying the effects of irisin on fat metabolism and muscle growth. Together, vitamin D and irisin may play complementary roles in improving metabolic function, fat burning, and muscle health. (36,37,38)

6. Taurine:

Taurine, an amino acid found in various foods and often used in supplements, is known for its wide range of health benefits. It is naturally present in high concentrations in the brain, eyes, heart, and muscles. Taurine supports several vital bodily functions, including cardiovascular health, muscle function, and overall metabolic regulation. (39)

How Taurine Works: Taurine maintains cellular health and regulates various physiological processes. It has antioxidant properties, helps to reduce inflammation, and supports cardiovascular health. Taurine also regulates energy metabolism and can influence how the body processes fat and glucose. Studies have shown that taurine supplementation can increase oxygen consumption and promote the expression of proteins involved in mitochondrial respiration, which enhances energy expenditure. (39,40)

Synergistic Effects: Supplementing with taurine can enhance the effects of irisin, especially when combined with physical exercise. Research demonstrates that taurine supplementation, along with exercise, can significantly elevate irisin levels, a myokine involved in energy metabolism and fat conversion. The combined action of taurine and irisin can improve energy expenditure, resting metabolic rate, and the crosstalk between muscle and fat tissues, making it a promising strategy for obesity management. While irisin boosts fat metabolism and supports metabolic enhancement during exercise, taurine amplifies these effects by improving the body’s ability to utilize irisin, potentially promoting better weight control and metabolic health. (39,40)

7. Ursolic Acid:

Ursolic acid is a natural compound found in various herbs and fruits, such as apples, rosemary, and holy basil. Known for its antioxidant and anti-inflammatory properties, ursolic acid has been used in traditional medicine for its potential health benefits. (41)

How Ursolic Acid Works: Ursolic acid is celebrated for reducing body fat, improving glucose tolerance, and enhancing insulin sensitivity. In studies with mice, ursolic acid significantly reduced body weight, adipose tissue mass, and fat accumulation, particularly in epididymal and subcutaneous fat. It achieves this by decreasing gene expression in fat cell formation and lipogenesis. Furthermore, ursolic acid promotes the “beiging” of white adipose tissue (WAT), transforming energy-storing white fat into energy-burning brown fat, thus improving metabolic function. It also stimulates the expression of proteins like PRDM16, PGC-1α, and FNDC5, which are crucial for energy expenditure and muscle health. (41,42,43)

Synergistic Effects: Supplementing with ursolic acid can complement the effects of irisin by promoting muscle growth and supporting the conversion of white fat to brown fat. Research shows that ursolic acid stimulates irisin secretion, which plays a key role in energy metabolism and fat burning. Together, irisin and ursolic acid enhance the burning of white fat and support muscle mass maintenance, leading to improved metabolic health. This combination may help reduce fat accumulation, increase energy expenditure, and promote better overall metabolic function. (41,42,43)

8. Gynostemma:

Gynostemma, a herb commonly used in traditional Chinese medicine, is praised for its wide range of health benefits. Known for its adaptogenic and antioxidant properties, Gynostemma has recently garnered attention for its potential impact on metabolic health and fat management. (44)

How Gynostemma Works: Gynostemma is rich in bioactive compounds, particularly gypenosides, contributing to its beneficial effects. Studies show that gypenosides can support cholesterol reduction, blood sugar regulation, and antioxidant activity. Gynostemma extract (GPE) has also been linked to improved mitochondrial metabolism, muscle differentiation, and enhanced exercise tolerance. The activation of the AMPK and PGC-1α signaling pathways by Gynostemma leads to increased fat oxidation, enhanced glucose uptake, and anti-oxidative stress, making it particularly valuable for those looking to improve endurance and metabolic health. Additionally, gypenosides may promote the browning of white fat tissue and regulate lactate metabolism, further supporting energy balance and fat management. (44,45)

Synergistic Effects: When combined with irisin, a hormone that facilitates the browning of white fat cells, Gynostemma can provide a synergistic effect. Irisin’s role in converting white fat to brown fat complements Gynostemma’s ability to enhance fat metabolism, improve glucose uptake, and increase antioxidant activity. Together, these actions support better metabolic health, fat management, and endurance, making Gynostemma a valuable component in metabolic and weight management strategies. (44,45)

9. Hesperidin:

Hesperidin, a flavonoid found primarily in citrus fruits, is celebrated for its antioxidant and anti-inflammatory properties. Often used as a dietary supplement, hesperidin is known for its potential to support cardiovascular health, improve circulation, and offer various metabolic benefits. (46)

How Hesperidin Works: Hesperidin acts as a potent antioxidant, reducing inflammation and neutralizing free radicals. Not only does it improve blood vessel function and circulation, but it also supports metabolic health. Recent research demonstrates that the active constituents of citrus fruit such as Mandarin, including hesperidin and polymethoxyflavonoids, can stimulate the secretion of irisin and its downstream mediators, such as PGC‐1α, PPARγ, and UCP‐1, all of which are critical in adipose tissue browning. This process promotes fat conversion, which can lead to better body composition and fat management. (46,47)

Synergistic Effects: Supplementing with hesperidin enhances fat metabolism by improving circulation and reducing inflammation. Its ability to stimulate irisin secretion, alongside irisin’s role in converting white fat to brown fat, amplifies these effects. This synergy between hesperidin and irisin promotes a healthier body composition and supports effective fat loss, particularly in the context of metabolic syndrome. (46,47)

Popular Supplements:

In this section, we introduce a range of popular supplements that not only support fat loss and metabolism but may also enhance the production and function of irisin, a hormone linked to fat metabolism and muscle growth. Each supplement combines ingredients that work synergistically to boost overall metabolic function and support body composition goals. Let’s take a closer look at each product:

Blackstone Labs Recomp Rx
Life Extension AMPK Metabolic Activator
Irwin Naturals Inflamma Less
REPP Sports Raze
InnovaPharm GENESIS-1

Blackstone Labs Recomp Rx:

Blackstone Labs Recomp Rx is designed to aid in fat loss while promoting muscle preservation. The formula includes ursolic acid, a key compound linked to irisin production, which helps convert white fat into brown fat, thereby enhancing fat metabolism.†

Key Ingredients:

Ursolic Acid (from Rosmarinus Officinalis and Loquat extract): Ursolic acid is a potent compound that can stimulate irisin secretion, encouraging fat tissue browning. (41,42,43)
Oleanolic Acid: Another component that may contribute to fat metabolism and improve overall metabolic health. (48)
Banaba Leaf Extract (Corosolic Acid): Known for supporting healthy blood sugar levels and fat utilization. (49)

Why These Ingredients Work Well Together:

Ursolic acid and corosolic acid complement each other by both promoting fat metabolism and helping to stabilize blood sugar levels, which can further support body composition changes.†

How To Take Recomp Rx:

The manufacturers recommend taking (1) capsule three (3) times daily with meals. Continue for 6-weeks followed by 2-weeks off. Repeat cycle.

Customer Review By Adam: “Recomp RX is tried and true. Been getting great results over the past few months. Highly recommend.”

Life Extension AMPK Metabolic Activator:

This supplement activates AMPK, a crucial enzyme that helps regulate energy balance and fat metabolism. It supports mitochondrial health and fat loss, making it a solid option for optimizing metabolic function.†

Key Ingredients:

Hesperidin (from Orange Extract): Hesperidin has been shown to increase irisin levels and support fat browning. It also improves circulation and reduces inflammation. (46,47)
Gynostemma Extract (Actiponin®): This powerful adaptogen supports AMPK activation, helping the body better manage energy and fat storage. (44,45)

Why These Ingredients Work Well Together:

Hesperidin enhances irisin activity, while Gynostemma increases AMPK activation. Together, they work to increase energy expenditure and promote fat loss, supporting optimal metabolic function.†

How To Take AMPK Metabolic Activator:

The manufacturers recommend taking one (1) tablet daily or as recommended by a healthcare practitioner.

Customer Review By Tara: “I’ve been using this r for a bit now, and I’m really happy with the results. It’s helped boost my energy and I’ve noticed some improvements around stubborn belly fat.”

Irwin Naturals Inflamma Less:

A comprehensive anti-inflammatory formula, Irwin Naturals Inflamma Less targets inflammation that can impede fat metabolism and overall metabolic health. It supports a balanced inflammatory response while promoting joint and cardiovascular health.†

Key Ingredients:

Hesperidin (Citrus spp. Extract): Known to stimulate irisin, hesperidin contributes to fat browning and improved metabolic function. (46,47)
Fish Oil (Omega-3 fatty acids): Helps reduce inflammation, supporting metabolic health and fat loss. (29)
Boswellia Serrata, Turmeric, Quercetin, Ginger Extract: These anti-inflammatory ingredients work together to combat oxidative stress, inflammation, and support overall metabolic health. (50,51,52,53)
Resveratrol: Provides antioxidant benefits and supports healthy aging and fat metabolism. (31,32)

Why These Ingredients Work Well Together:

This blend of anti-inflammatory compounds, combined with hesperidin’s irisin-stimulating properties, promotes a balanced inflammation response and enhances fat metabolism.†

How To Take Irwin Naturals Inflamma Less:

The manufacturers recommend taking two (2) Liquid Soft-Gels with a full glass (8 oz) of water twice a day on an empty stomach as needed.

Customer Review By Sandy: “I’ve been using Inflamma-Less for a few weeks, and it’s made a noticeable difference in how my body feels after workouts. I love that it supports my body’s natural response to inflammation without any harsh ingredients.”

REPP Sports Raze:

REPP Sports Raze is designed to provide energy, boost fat loss, and enhance focus during workouts. This thermogenic formula utilizes a blend of ingredients that enhance fat-burning mechanisms while supporting overall metabolic health.†

Key Ingredients:

Hesperidin (from Citrus Aurantium): Increases irisin levels, aiding in the conversion of white fat to brown fat for better fat metabolism. (46,47)
Synephrine (from Citrus Aurantium): A powerful stimulant that enhances fat-burning processes. (54,55)
Mucuna Pruriens: Supports dopamine production and mood, which may help improve workout performance and recovery. (56,57)
Theobromine & Caffeine: Provide energy and enhance thermogenesis, helping to burn fat during physical activity. (34)

Why These Ingredients Work Well Together:

Combining hesperidin, synephrine, and thermogenic stimulants like caffeine creates a potent fat-burning formula that can help support energy and fat metabolism during intense workouts.†

How To Take Repp Sport Raze:

As with any dietary supplement, test your body’s tolerance first. The manufacturers recommend starting by taking one capsule daily with breakfast every morning for the first three days. The effects should be long-lasting, but if they continue over 15 hours, adjust the routine to one serving every other day.

Over time, the dosage may be increased. You can take a second pill NO LESS THAN 8 HOURS after the previous pill.

For added performance: Drink 64 ounces of water daily while using this product.
To avoid sleeplessness: Do not take 5 within 5 hours of bedtime. DO NOT consume more than 2 servings in any 24 hour period.

Customer Review By Charlie: “Good energy that lasts. Haven’t weighed myself but looks like I lost weight since using this fat burner.”

InnovaPharm GENESIS-1:

InnovaPharm GENESIS-1 is a unique supplement aimed at promoting muscle growth, recovery, and fat loss by leveraging growth factors and specialized compounds that boost cellular health.†

Key Ingredients:

IGF-1, IGF-2, FGF, NGF, EGF, CTGF: These growth factors support muscle development, tissue repair, and overall recovery, enhancing fat loss and lean muscle growth. (58,59,60,61,62)
Follistatin: Aids in muscle growth by inhibiting myostatin, a protein that limits muscle development. (63)
TGF (Transforming Growth Factor Beta): Supports cellular repair and recovery, which can improve overall metabolic efficiency. (64)

Why These Ingredients Work Well Together:

The growth factors work synergistically to enhance muscle growth and fat metabolism. By improving muscle repair and inhibiting myostatin, GENESIS-1 helps build lean muscle mass, enhancing fat loss by increasing metabolic demand.†

How To Take InnovaPharm GENESIS-1:

The manufacturers recommend taking 1 capsule in the morning and 1 capsule in the evening. Use daily and for prolonged periods for maximum results.

Customer Review By Jeff: “Great product. Saw and felt a noticeable difference in my strength and recovery while taking it. Overall very pleased.”

What Should You Try:

Choosing the right supplement depends on your specific goals, whether it’s fat loss, muscle preservation, improving metabolic health, reducing inflammation, or enhancing recovery. Here’s a breakdown of which product might work best for your individual needs:

Blackstone Labs Recomp Rx:

Best for: Individuals focused on body recomposition — those looking to lose fat while maintaining or building muscle.†
This product is ideal for athletes or fitness enthusiasts aiming to convert fat into energy while preserving muscle mass. The inclusion of ursolic acid supports fat browning and metabolic health, while corosolic acid helps regulate blood sugar, making it great for those looking to optimize fat loss without sacrificing strength or muscle tissue.†

Life Extension AMPK Metabolic Activator:

Best for: Those seeking to boost metabolism and improve energy balance, particularly if they’re focused on overall health and longevity.†
This supplement is a great option for people looking to increase their metabolic rate through AMPK activation, which helps the body burn fat more efficiently. With ingredients like hesperidin, which enhances irisin production, and gynostemma extract, it’s perfect for individuals who want to support mitochondrial health and reduce fat storage without using stimulants.†

Irwin Naturals Inflamma Less:

Best for: Individuals dealing with inflammation, joint pain, or those wanting to optimize their body’s inflammatory response.†
This formula is ideal for people whose fat loss or muscle-building efforts may be hindered by chronic inflammation. Ingredients like fish oil, turmeric, and boswellia serrata provide strong anti-inflammatory benefits, while hesperidin helps promote fat browning through irisin production. It’s particularly suited for those who prioritize joint health and overall recovery while working toward fitness goals.†

REPP Sports Raze:

Best for: Those seeking high-energy, fat-burning support, especially around workouts.†
REPP Sports Raze is great for individuals looking for a thermogenic boost during exercise. If you need an extra energy kick, enhanced focus, and fat-burning support, the synephrine, caffeine, and theobromine in this blend will help you power through workouts. It’s best for those who are not sensitive to stimulants and want a multi-faceted product that enhances both fat loss and mental clarity.†

InnovaPharm GENESIS-1:

Best for: Those focused on muscle recovery, tissue repair, and overall growth.†
If your primary goal is building muscle and enhancing recovery, GENESIS-1 is your go-to. It’s especially beneficial for those who engage in intense workouts and need to repair and grow muscle tissue efficiently. With a blend of IGF-1, IGF-2, and various growth factors, it supports lean muscle development and cellular repair, making it a solid option for those prioritizing muscle health and long-term physical performance.†

Wrapping Up!

And this marks the end of our post on Irisin. Thank you for reading! And as always, if there was something that wasn’t clear, another question you might have, or if you have another idea for a blog, Email Us!

Looking for more to read? Check out some of our other blogs!

Warnings And Side Effects:

Check with your doctor before using the products mentioned in this post to see if you are using medication or have any medical conditions. Do not use if you may become pregnant, are pregnant or nursing. Do not exceed recommended daily intake. Not intended for use by persons under 18. Keep out of reach of children. Store in a cool, dry place.

Disclaimer:

†Please note the intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While we aim to maintain and display accurate information, we can’t guarantee it represents the latest product formulation or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturers’ and users’ views and information. Additionally, the Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent disease or illness.