The Estrobolome and Estrogen Dominance: Supplements That Support Gut Health for Hormone Balance

November 4, 2024 Talib Ahmad Supplement Expert 206 Views

Are you experiencing stubborn weight gain, mood swings, or fatigue that just doesn’t seem to go away? These could be signs of estrogen dominance—a common hormonal imbalance that affects many people, particularly women. Hormones play a powerful role in our health, and when they’re out of balance, we can feel it in many ways.

What if we told you that your gut health, specifically a part of your microbiome called the estrobolome, has a big impact on estrogen levels? The estrobolome consists of specific gut bacteria that help process and regulate estrogen in the body. When it’s working well, these bacteria help keep estrogen levels balanced, which may prevent those frustrating symptoms of estrogen dominance.

In this article, we’ll explore the important link between the estrobolome and estrogen metabolism, and we’ll introduce you to supplements that can support a healthy gut and promote hormonal balance. By taking care of your gut, you may just find a natural path to feeling better and more balanced.†

What is Estrogen Dominance?

Estrogen dominance is a hormonal imbalance that occurs when there’s too much estrogen in the body relative to other hormones, especially progesterone. Estrogen and progesterone are key hormones in both women’s and men’s health, affecting everything from mood to metabolism. Ideally, these hormones work together in harmony, balancing each other out. But when estrogen levels become too high or progesterone levels drop too low, that balance is lost. This can lead to symptoms that significantly impact how we feel daily. (1,2)

Common Symptoms of Estrogen Dominance:

For many, the signs of estrogen dominance can range from mildly inconvenient to quite disruptive. Here are some common symptoms: (1,2,3,4,5,6)

Weight Gain: Especially around the hips, thighs, and abdomen.†
Mood Swings and Anxiety: Hormones have a powerful effect on our mood, and too much estrogen can increase irritability, anxiety, or even depression.†
Fatigue: Feeling constantly tired, even after a full night’s sleep, can be a sign that your hormones aren’t balanced.†
PMS Symptoms: Worsened PMS, including bloating, tender breasts, and headaches, is a common sign of excess estrogen.†
Irregular Periods: High estrogen levels can disrupt the menstrual cycle, causing irregular or heavy periods.†
Other Symptoms: Low libido, memory problems, and sleep disturbances are also possible indicators of estrogen dominance.†

Since these symptoms are fairly common, they can easily be mistaken for general stress, aging, or dietary issues. However, if you’re experiencing several of these symptoms at once, it might be worth considering if estrogen dominance could be the underlying issue. Additionally, excess estrogen in men may present with symptoms such as infertility, erectile dysfunction, and gynecomastia. (2,3)

Causes of Estrogen Dominance:

So, why does estrogen dominance happen in the first place? It can result from a variety of factors, both internal and external, including:

Hormonal Changes: Natural changes, such as puberty, perimenopause, and menopause, can lead to shifts in estrogen and progesterone levels. (7)
Diet: Diets high in processed foods, sugars, and red meats and low in fiber can influence estrogen levels. (8)
Environmental Factors: We’re often exposed to chemicals known as endocrine disruptors in plastics, household cleaners, cosmetics, and even in our water. These chemicals can mimic estrogen in the body, contributing to hormonal imbalances. (1,9)
Liver Health: The liver plays a crucial role in breaking down and eliminating excess estrogen. When liver function is compromised (due to diet, alcohol, or other factors), it can lead to a buildup of estrogen. (10)

Why Estrogen Dominance Matters for Health:

Long-term estrogen dominance can be more than just an inconvenience. Over time, elevated estrogen levels may increase the risk of more serious health issues, such as: (1,2,3)

Fibroids and Endometriosis: Excess estrogen can contribute to the growth of fibroids and endometrial tissue.†
Breast and Endometrial Cancer: High estrogen levels over extended periods can raise the risk of certain cancers.†
Thyroid Dysfunction: Estrogen dominance can interfere with thyroid function, leading to symptoms like fatigue, weight gain, and cold intolerance.†

Understanding the root causes of estrogen dominance can help in finding effective ways to address it. In many cases, supporting the body’s natural processes, particularly the liver and gut, can be a game-changer. That’s where the estrobolome comes in—a lesser-known but crucial part of our gut microbiome that plays a significant role in estrogen balance.†

Understanding the Estrobolome:

The estrobolome is a lesser-known but influential part of our gut microbiome—a collection of bacteria that specifically help regulate estrogen levels. This group of bacteria is responsible for metabolizing estrogen, meaning it helps break down and process estrogen so it can be used or eliminated by the body. When the estrobolome is healthy and functioning properly, it plays a crucial role in maintaining a balanced level of estrogen, which can help prevent many of the symptoms associated with estrogen dominance. (11,12,13)

What is the Estrobolome?

The term “estrobolome” refers to a subset of gut bacteria that produce enzymes capable of metabolizing estrogens. These bacteria influence the estrogen balance in the bloodstream by helping to activate or deactivate estrogen and facilitating its elimination through the digestive tract. A well-functioning estrobolome supports the body’s natural estrogen detoxification process, helping to maintain hormonal balance and prevent excess estrogen from building up. (11,12,13)

Estrogen undergoes several steps in the body before it is finally eliminated. First, it’s processed in the liver, which prepares it for removal, then it’s sent to the intestines, where the estrobolome steps in. This process can either lead to the proper elimination of estrogen or, if the estrobolome is imbalanced, to the reabsorption of estrogen back into the bloodstream, leading to higher levels in the body. (14)

Why the Estrobolome is Important for Hormone Balance:

A balanced estrobolome is essential for a healthy estrogen balance, and here’s why: (11,12,13)

Estrogen Detoxification: A well-functioning estrobolome ensures that estrogen is broken down effectively and eliminated from the body.†
Hormone Regulation: The estrobolome helps to regulate the overall levels of estrogen, which affects not only reproductive health but also mood, energy, and even bone density. An imbalanced estrobolome may result in an excess or deficiency of estrogen, both of which can disrupt the delicate hormonal balance needed for optimal health.†
Connection to Gut Health: Gut health and hormone health are closely connected. When gut bacteria are diverse and well-balanced, they support healthy estrogen metabolism. Conversely, poor gut health (due to diet, stress, or antibiotics) can disrupt the estrobolome and lead to hormonal imbalances.†

The Gut-Estrogen Connection:

Estrogen is primarily processed in the liver, which converts into a form the body can remove. Once this estrogen has been processed, it travels to the intestines, where it’s meant to be excreted from the body. However, the elimination process can be interrupted if the gut isn’t functioning optimally. This is where the estrobolome, the specific part of the microbiome that regulates estrogen, comes into play. (14)

The estrobolome produces enzymes that help break down estrogen in the intestines to safely remove it from the body. When the estrobolome is healthy and balanced, it ensures that excess estrogen is eliminated. However, if the estrobolome is disrupted by poor diet, stress, or other factors, it may start reactivating estrogen that was meant for excretion, sending it back into the bloodstream. This process, called “reabsorption,” can increase circulating estrogen levels and contribute to estrogen dominance. (11,12,13)

Signs That Gut Health May Be Impacting Your Hormones

If your gut is out of balance, you might notice a mix of digestive and hormonal symptoms. Some common signs that your gut health could be affecting your estrogen levels include: (12,13,15,16,17)

Frequent Bloating or Gas: Excessive bloating and gas can indicate a gut bacteria imbalance, which interferes with the estrobolome’s function.†
Irregular Digestion: Constipation or irregular bowel movements can slow the elimination of estrogen, giving it more time for reabsorption.†
Hormonal Symptoms: If you’re experiencing symptoms like mood swings, stubborn weight gain, or low energy, your gut health may be contributing to estrogen dominance.†
Skin Issues: Acne or other skin problems can be signs of both gut imbalance and hormone fluctuations, as the skin often reflects what’s happening internally.†

Factors That Disrupt the Gut-Estrogen Connection

Several lifestyle and environmental factors can disrupt the balance of the estrobolome, leading to a higher risk of estrogen dominance. Here are some of the common factors:

Diet Low in Fiber: Fiber is essential for supporting gut health and helping eliminate excess estrogen. (18)
High Sugar and Processed Foods: Diets high in sugar and processed foods can feed harmful bacteria in the gut, creating an imbalance that may disrupt estrogen regulation. (19)
Antibiotics and Certain Medications: Antibiotics can kill beneficial bacteria along with harmful ones, which may throw off the balance of the microbiome and hinder the estrobolome’s ability to process estrogen effectively. (20)
Chronic Stress: Long-term stress can negatively impact gut health by disrupting the balance of gut bacteria, slowing digestion, and increasing inflammation, all of which can impair estrogen metabolism. (21)
Environmental Toxins: Exposure to chemicals known as xenoestrogens—found in plastics, pesticides, and certain personal care products—can mimic estrogen in the body, adding to the estrogen load and potentially overwhelming the gut’s ability to maintain balance. (1,9)

Supplements That Support the Estrobolome and Hormone:

When it comes to maintaining balanced hormones, particularly estrogen, gut health plays a pivotal role. For those experiencing symptoms of estrogen dominance or wanting to support their body’s natural hormone regulation, certain supplements can enhance the health of the estrobolome, the unique subset of gut bacteria that metabolize and regulate estrogen. Here’s a look at some of the most effective supplements for promoting a healthy estrobolome and aiding in hormone balance.

Probiotics
Prebiotics
Calcium D-Glucarate
DIM (Diindolylmethane)
Fiber Supplements
L-Glutamine
Black Cohosh
Chasteberry (Vitex)
Indole-3-Carbinol (I3C)
Magnesium

Probiotics:

Probiotics are live beneficial bacteria that can help restore balance in the gut microbiome, a key player in managing estrogen levels in the body. The estrobolome, a subset of gut bacteria specifically involved in estrogen metabolism, relies on a healthy and balanced microbiome to function optimally. (22,23,24)

How Probiotics Help with Estrogen Dominance: Probiotics can support the gut’s ability to break down estrogen and prevent it from reabsorbing into the body. They enhance the health and function of the estrobolome, promoting a bacterial environment that favors proper estrogen metabolism and excretion. (22,23,24)
Recommended Strains: Certain probiotic strains like Lactobacillus and Bifidobacterium are particularly helpful in maintaining a healthy gut environment and may be more effective in supporting the estrobolome’s role in estrogen regulation. (25)

How To Take PB8 Probiotic:

The manufacturers recommend that adults take (2) capsules per day.

Prebiotics:

Prebiotics are fibers that nourish the beneficial bacteria in the gut, indirectly supporting estrogen metabolism. Since prebiotics are essentially “food” for probiotics, they help to maintain a healthy population of bacteria, including those within the estrobolome. By enhancing the diversity and health of gut bacteria, prebiotics support the estrobolome’s ability to metabolize estrogen. (24, 26)

How Prebiotics Help with Estrogen Dominance: Prebiotics support the growth and activity of beneficial bacteria that help metabolize estrogen. By fostering a diverse gut environment, prebiotics contribute to a balanced estrobolome, aiding in the breakdown of estrogen and helping prevent symptoms associated with estrogen dominance. (24, 26)
Sources of Prebiotics: In addition to supplements, prebiotic-rich foods such as onions, garlic, asparagus, and oats can provide natural support for gut health and hormone balance.†

How To Take NOW Inulin:

The manufacturers recommend taking 1 level teaspoon 1 to 3 times daily. Mix into your favorite beverage or food. Begin with 1 teaspoon a day and slowly increase the dosage to limit GI discomfort.

Calcium D-Glucarate:

Calcium D-glucarate is a supplement that supports the body’s natural detoxification processes, particularly in the liver, where it helps to break down and remove excess estrogen. It works by inhibiting an enzyme called beta-glucuronidase, which, if overactive, can cause estrogen to be reabsorbed into the bloodstream rather than being eliminated. (27)

How Calcium D-Glucarate Helps with Estrogen Dominance: By blocking beta-glucuronidase, calcium D-glucarate promotes the efficient excretion of estrogen. This helps prevent estrogen from re-entering circulation and contributing to estrogen dominance, making it particularly useful for those looking to reduce symptoms like bloating, fatigue, and hormonal imbalances. (27)

How To Take NOW Calcium D-Glucarate?

The manufacturers recommend taking 1 capsule 3 times daily. Store in a cool, dry place after opening.

DIM (Diindolylmethane):

DIM is a compound in cruciferous vegetables like broccoli and cauliflower. It helps metabolize estrogen by promoting the production of “good” estrogen metabolites, which have a less potent effect on the body than other, more aggressive estrogen forms. DIM also supports the liver’s ability to process estrogen efficiently. (28,29)

How DIM Helps with Estrogen Dominance: DIM encourages the conversion of estrogen into less active forms, supporting a healthier balance and reducing the buildup of more potent estrogens that can lead to estrogen dominance. This makes DIM particularly valuable for managing symptoms like breast tenderness and mood swings. (28,29)

How To Take Swanson DIM Complex:

The manufacturers recommend taking one capsule one to three times per day with water before meals.

Fiber Supplements:

Fiber plays a crucial role in digestive health, supporting the elimination of waste, including excess estrogen. It binds to estrogen in the intestines, helping to carry it out of the body and reduce the likelihood of it being reabsorbed into the bloodstream. A diet rich in fiber is beneficial for gut health overall, and fiber supplements can help those who struggle to get enough from food sources alone. (26,30)

How Fiber Helps with Estrogen Dominance: Fiber supports the efficient elimination of estrogen, helping to prevent reabsorption and maintain hormonal balance. Soluble fibers, such as those from flaxseed, psyllium husk, and oats, are particularly effective in this process, acting as a natural “cleanser” for the digestive system. (26,30)

How To Take Kirkland Fiber Capsules:

The manufacturers recommend adults take 2-6 capsules for increasing daily fiber intake and 6 capsules for cholesterol-lowering programs. Take this product with 8 oz of water (swallow 1 capsule at a time) up to 3 times daily.

New users: Start with 1 serving per day; gradually increase to 3 servings per day as necessary. As your body adjusts to increased fiber intake, you may initially experience changes in bowel habits or minor bloating.

NOTICE: Take this product with at least 8 oz (a full glass) of liquid. Taking it without enough liquid may cause choking. Do not take it if you have difficulty swallowing.

Diets low in saturated fat and cholesterol that include 7 grams of soluble fiber per day from psyllium seed husk may reduce the risk of heart disease by lowering cholesterol levels. One serving provides 2.4 grams of this soluble fiber. Consult a doctor if you are considering the use of the product as part of a cholesterol-lowering program.

L-Glutamine:

L-glutamine is an amino acid that supports the integrity of the gut lining, which is vital for overall gut health and hormone balance. By promoting a strong intestinal barrier, L-Glutamine helps prevent substances, including estrogen, from leaking back into circulation. (31,32)

How L-Glutamine Helps with Estrogen Dominance: By strengthening the gut lining, it reduces the risk of estrogen reabsorption, thus supporting proper elimination and reducing the chances of estrogen buildup. It’s also beneficial for overall gut health, helping to reduce inflammation that could disrupt hormone regulation. (31,32)

How To Take EAS L-Glutamine:

The manufacturers recommend taking one (1) scoop of L-Glutamine Powder with 8 oz. water or your favorite beverage or use as directed by a physician or licensed nutritionist.

Black Cohosh:

Black cohosh is a plant-based supplement often used to relieve symptoms of menopause. It contains phytoestrogens—plant compounds that can mimic estrogen’s effects in the body, which may help modulate estrogen levels. Black cohosh supports hormonal balance, particularly in women experiencing hormonal fluctuations. (33,34)

How Black Cohosh Helps with Estrogen Dominance: By acting as a phytoestrogen, black cohosh can help regulate estrogen activity in the body, potentially reducing symptoms of estrogen dominance. It’s especially useful for managing symptoms like hot flashes, night sweats, and mood swings. (33,34)

How To Take Swanson Hormone Essentials:

The manufacturers recommend taking one capsule three times per day with food and water.

Chasteberry (Vitex):

Chasteberry, also known as Vitex, is a powerful herb for hormonal balance. It works by influencing the pituitary gland to regulate hormone production, particularly progesterone. By increasing progesterone levels, chasteberry can help balance high estrogen levels, effectively reducing estrogen dominance symptoms. (34,35)

How Chasteberry Helps with Estrogen Dominance: Since estrogen dominance is often linked with low progesterone, chasteberry helps restore this balance. This can reduce symptoms such as irregular periods, PMS, and mood swings. Vitex is commonly used to support reproductive health and maintain balanced hormone levels. (34,35)

How To Take Nature’s Way Vitex:

The manufacturers recommend taking 1 capsule two or three times daily for 8-12 weeks. After that, take 1 capsule daily. Best results obtained with continuous use.

Indole-3-Carbinol (I3C):

Indole-3-Carbinol (I3C) is a compound in cruciferous vegetables like broccoli and cabbage. It supports estrogen metabolism in the liver, promoting the conversion of estrogen into less active metabolites that the body can eliminate more easily. This process is crucial for maintaining balanced estrogen levels. (28,36)

How I3C Helps with Estrogen Dominance: I3C aids in the breakdown of estrogen into safer, less potent forms, helping to prevent estrogen buildup in the body. By supporting liver detoxification, I3C reduces the risk of estrogen reabsorption and lowers the likelihood of symptoms associated with estrogen dominance. (28,36)

How To Take NOW Indole 3 Carbinol:

The manufacturers recommend taking 1 capsule 1 to 2 times daily with food.

Magnesium:

Magnesium is a mineral essential for numerous bodily processes, including hormone regulation and gut motility. It supports liver detoxification and promotes regular bowel movements, which are crucial for eliminating excess estrogen from the body. Additionally, magnesium has a calming effect on the body, which can help reduce stress-related hormone imbalances. (37,38)

How Magnesium Helps with Estrogen Dominance: Magnesium supports the body’s natural detox pathways, helping to flush out excess estrogen. It also reduces stress, which can otherwise contribute to hormonal imbalance. By aiding digestion and promoting relaxation, magnesium helps create a more balanced hormonal environment. (37,38)

How To Take Life Extension Magnesium:

The manufacturers recommend taking one (1) capsule one to three times daily or as recommended by a healthcare practitioner.

What Should You Try:

When deciding which supplements to try for estrogen balance and gut health, it’s essential to consider your unique health needs, symptoms, and lifestyle. Each of the supplements discussed has specific roles in supporting estrogen metabolism and promoting a healthy estrobolome, so here’s a guide to help you determine which may be most beneficial for you:

For Gut Health and Estrogen Detox Support

If you suspect that your gut health may be affecting your hormone balance or have digestive symptoms like bloating, irregular bowel movements, or discomfort:

Probiotics: Start here if you’re looking to improve overall gut health and balance your microbiome. Probiotics can support a healthy estrobolome, helping your body break down estrogen efficiently.†
Prebiotics: If you’re already taking probiotics, consider adding prebiotics to “feed” beneficial bacteria and enhance their effectiveness. This combination is especially helpful if you’re focusing on long-term gut support.†
Fiber Supplements: If you struggle to get enough fiber from your diet, a supplement can ensure regular bowel movements, reducing the chance of estrogen reabsorption.†
L-Glutamine: If you experience symptoms like bloating, indigestion, or leaky gut, L-Glutamine can help strengthen the gut lining and promote a healthier intestinal barrier.†

For Direct Estrogen Metabolism Support

If your main focus is reducing symptoms of estrogen dominance, like PMS, mood swings, and bloating, these supplements can be particularly effective:

Calcium D-Glucarate: This is ideal for those who want to boost liver detoxification and prevent estrogen reabsorption. If you experience estrogen dominance symptoms or are undergoing hormone therapy, Calcium D-Glucarate can support efficient estrogen breakdown and excretion.†
DIM (Diindolylmethane): A good choice if you want to reduce potent estrogens in favor of more benign forms. DIM works well if you experience PMS symptoms or mild estrogen dominance. It may also be helpful for those who don’t get enough cruciferous vegetables.†
Indole-3-Carbinol (I3C): Similar to DIM, I3C also supports estrogen metabolism and is especially beneficial for liver health. It’s a good choice if you prefer a natural compound found in foods like broccoli and cabbage.†

For Hormonal Balance and Menstrual Health

If you experience irregular periods, PMS, or menopausal symptoms, these supplements may offer targeted support:

Chasteberry (Vitex): Often used for menstrual health, Vitex can help balance estrogen and progesterone. This makes it an excellent option if you experience PMS or irregular periods. It’s especially helpful for those with low progesterone, which often contributes to estrogen dominance.†
Black Cohosh: Best for perimenopause or menopause as it can help reduce hot flashes and other menopausal symptoms. If your estrogen dominance symptoms are tied to hormonal changes during menopause, this plant-based option may offer relief.†

For Overall Health and Stress Reduction

If you’re interested in maintaining a balanced lifestyle that supports hormone health and reduces stress:

Magnesium: Magnesium is a great foundational supplement that supports relaxation, sleep quality, and hormone balance. It’s particularly useful for those with high-stress levels and may help with gut health regularity for optimal estrogen excretion.†

Popular Hormone Balancing Blends:

If you’re exploring supplement blends designed to balance hormones and improve overall well-being, here’s a detailed look at six popular options. Each product offers a unique mix of ingredients to support hormone regulation, gut health, and more.

Bucked Up Babe Balance
Blackstone Labs Harmonize
Irwin Naturals EstroPause Menopause Support
Universal Nutrition Animal Alpha F
Alani Nu Balance
Alpha Lion SuperHuman Woman

Bucked Up Babe Balance

This blend combines foundational nutrients with targeted herbal ingredients to support hormonal balance, stress reduction, and estrogen metabolism.†

Key Ingredients and Benefits:

Magnesium (105mg): Relaxes muscles and regulates neurotransmitters, helping to ease PMS symptoms such as cramps and irritability. (39)
Selenium (55mcg): Supports thyroid health, which plays a critical role in hormone regulation. (40)
Chromium (70mcg): Helps stabilize blood sugar levels, indirectly supporting hormonal balance by reducing insulin spikes. (40)
Inositol (1000mg): Improves ovarian function, particularly for women with PCOS, by enhancing insulin sensitivity and restoring regular cycles. (41)
DIM (100mg): Aids in metabolizing estrogen into its beneficial forms, reducing symptoms like bloating, mood swings, and acne associated with estrogen dominance. (28,29)
Chasteberry Extract (100mg): Balances estrogen and progesterone, supporting cycle regularity and relieving PMS symptoms. (34,35)
Ashwagandha (50mg): Reduces cortisol, improving stress resilience and promoting a healthy hormonal environment. (42)
Black Cohosh (50mg): Eases menopausal symptoms, including hot flashes and mood swings, by mimicking estrogen’s effects in the body. (33,34)

Who It’s For:
This is an excellent option for women with irregular cycles, mild estrogen dominance, or stress-induced hormonal disruptions. It’s particularly well-suited for those managing PCOS or seeking relief from PMS symptoms.†

How To Take Bucked Up Babe Balance:

The manufacturers recommend taking 3 capsules with 6-8 oz of water daily.

Blackstone Labs Harmonize

This proprietary blend combines adaptogens, herbal extracts, and precursors to support mood, energy, and hormonal equilibrium.†

Key Ingredients and Benefits:

Maca Root (4:1): A natural adaptogen that supports energy, libido, and mood stability, particularly during hormonal fluctuations. (43)
Turmeric (95% curcuminoids): Offers potent anti-inflammatory properties that can reduce inflammation associated with hormonal imbalances. (44)
Mucuna Pruriens (98% L-Dopa): Boosts dopamine production, which helps regulate mood and counteract stress-related hormone imbalances. (45)
Epimedium Extract (10% Icariin): Known for improving blood flow and libido, indirectly supporting hormone health. (46)
Damiana Extract: May support hormonal health by enhancing mood and libido. (47)
Androsta-3,5-diene-7,17-dione: This aromatase inhibitor reduces excess estrogen levels, particularly beneficial for women with estrogen dominance or those looking to balance estrogen and testosterone ratios.†
DHEA: Acts as a precursor to estrogen and testosterone, helping maintain balance as natural production declines with age. (48)

Who It’s For:
Ideal for women experiencing mood swings, low energy, or libido issues tied to hormonal fluctuations. It also appeals to those looking for stress relief and hormonal support in one formula.†

How To Take Blackstone Labs Harmonize:

The manufacturers recommend taking 4 capsules daily upon awakening or 15-20 minutes before engaging in sexual activity. Do not exceed 4 capsules. Take daily for best results.

Irwin Naturals EstroPause Menopause Support

This blend targets symptoms of menopause with a combination of essential minerals, herbal extracts, and omega-3s to ease the transition.†

Key Ingredients and Benefits:

Fish Oil (647mg Omega-3s): Reduces inflammation, supports heart health, and eases joint pain, which can worsen during menopause. (49)
Soy Isoflavones (100mg): Acts as a phytoestrogen, mimicking estrogen’s effects to alleviate hot flashes and other menopausal symptoms. (50)
Black Cohosh (80mg): Well-researched for reducing hot flashes, night sweats, and mood swings in menopausal women. (33,34)
Chasteberry Extract (20mg): Helps balance fluctuating hormones, particularly by supporting progesterone levels. (34,35)
St. John’s Wort (300mg): Aids in managing mood disturbances, such as irritability and sadness, that often accompany menopause. (51)
Calcium (500mg) and Magnesium (200mg): Support bone health, a critical concern for women in menopause due to declining estrogen levels. (52,39)

Who It’s For:
This product is optimized for women in perimenopause or menopause who are dealing with hot flashes, mood swings, and declining bone health.†

How To Take Irwin Naturals EstroPause Menopause Support:

The manufacturers recommend taking two (2) to four (4) Liquid soft gels daily with meals. It may be taken all at once or divided throughout the day.

Universal Nutrition Animal Alpha F

Designed for active women, this blend focuses on detoxification, stress management, and overall hormonal support.†

Key Ingredients and Benefits:

Calcium-D-Glucarate (250mg): Enhances liver detoxification, aiding in the elimination of excess estrogen and reducing symptoms of estrogen dominance. (27)
DIM (100mg): Supports the healthy metabolism of estrogen, balancing estrogen levels in the body. (28,29)
Ashwagandha (300mg): An adaptogen that reduces cortisol, promoting a more balanced hormonal state. (42)
BioCell Collagen (100mg): Provides joint and skin support, particularly useful during hormonal changes. (53)
Gotu Kola and Eleuthero Root (100mg each): Offer adaptogenic and antioxidant benefits, reducing stress-related disruptions to hormonal health. (54,55)

Who It’s For:
Best suited for physically active women looking for comprehensive hormonal support alongside stress management and detoxification.†

How To Take Universal Nutrition Animal Alpha F:

The manufacturers recommend taking 1 pack with any meal.

Alani Nu Balance

A straightforward yet potent formula targeting hormone-related skin issues, cycle irregularities, and metabolic health.†

Key Ingredients and Benefits:

Myo-Inositol (2g): Aids in restoring ovarian function and hormone regulation, especially for women with PCOS. (41)
DIM (150mg): Supports estrogen balance and reduces symptoms of estrogen dominance like acne and bloating. (28,29)
Sodium R-Alpha Lipoic Acid (100mg): Provides antioxidant support, promoting insulin sensitivity and metabolic health. (56)
Setria Glutathione (250mg): Enhances detoxification, supporting liver function for efficient hormone metabolism. (57)

Who It’s For:
An excellent choice for women managing PCOS, hormonal acne, or cycle irregularities.†

How To Take Alani Nu Balance:

The manufacturers recommend taking 4 capsules once a day with a morning meal.

Alpha Lion SuperHuman Woman

This formula offers a robust combination of ingredients to support energy, hormonal balance, and mental clarity.†

Key Ingredients and Benefits:

Myo-Inositol (2g): Improves hormonal function and ovarian health, especially for cycle regularity. (41)
DIM (150mg): Promotes estrogen metabolism, reducing the impact of estrogen dominance. (28,29)
KSM-66 Ashwagandha (200mg): Reduces stress and cortisol levels, which can indirectly support better hormone health. (42)
L-Tyrosine (500mg): Enhances focus and mental clarity, often affected by hormonal fluctuations. (58)
Vitex (250mg): Balances estrogen and progesterone, supporting overall cycle health. (34,35)
Magnesium (250mg): Relieves PMS symptoms and promotes better sleep. (37,38)

Who It’s For:
Ideal for women seeking a multi-benefit supplement to address stress, energy, and hormonal balance.†

How To Take Alpha Lion SuperHuman Woman:

The manufacturers recommend mixing 1 scoop with 8-12 oz of water.

Which Blend is Right for You?

Choosing the best supplement depends on your specific needs:

For PCOS and insulin resistance: Bucked Up Babe Balance or Alani Nu Balance.†
For menopause support: Irwin Naturals EstroPause.†
For active lifestyles: Universal Nutrition Animal Alpha F.†
For stress and hormonal clarity: Alpha Lion SuperHuman Woman or Blackstone Labs Harmonize.†

Always consult with a healthcare provider to find the best option tailored to your health needs and goals.

Wrapping Up!

And this marks the end of our post on the estrobolome and estrogen dominance. Thank you for reading! And as always, if there was something that wasn’t clear, another question you might have, or if you have another idea for a blog, Email Us!

Are you looking for more to read? Check out some of our other blogs!

Warnings And Side Effects:

For adults only. Do not take products mentioned in this post if you are pregnant or nursing. Consult your healthcare provider before use if you are taking any prescription medication or if you have a medical condition, especially a liver disorder. Discontinue use if you experience gastrointestinal discomfort or develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice. Contains dong quai; avoid lengthy exposure to natural sunlight and other UV light sources as products in this post may increase your skin’s photosensitivity, resulting in sunburn or skin rash.

Keep out of reach of children. Do not use it if the seal is broken. Store in a cool, dry place.

Disclaimer:

†Please note the intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While we aim to maintain and display accurate information, we can’t guarantee it represents the latest product formulation or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturers’ and users’ views and information. Additionally, the Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent disease or illness.